K
Kim Jonas
Researcher at King's College London
Publications - 31
Citations - 672
Kim Jonas is an academic researcher from King's College London. The author has contributed to research in topics: G protein-coupled receptor & Receptor. The author has an hindex of 14, co-authored 26 publications receiving 606 citations. Previous affiliations of Kim Jonas include University of Kent & Imperial College London.
Papers
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Journal ArticleDOI
Rescue of defective G protein–coupled receptor function in vivo by intermolecular cooperation
Adolfo Rivero-Müller,Yen-Yin Chou,Inhae Ji,Svetlana Lajic,Aylin C. Hanyaloglu,Kim Jonas,Nafis A. Rahman,Tae H. Ji,Ilpo Huhtaniemi,Ilpo Huhtaniemi +9 more
TL;DR: In this paper, the mouse luteinizing hormone receptor (LHR) was used as a model GPCR, and it was shown that transgenic mice coexpressing binding-deficient and signalingdeficient forms of LHR can reestablish normal LH actions through intermolecular functional complementation of the mutant receptors.
Journal ArticleDOI
Single Molecule Analysis of Functionally Asymmetric G Protein-coupled Receptor (GPCR) Oligomers Reveals Diverse Spatial and Structural Assemblies
TL;DR: The findings reveal that diverse spatial and structural assemblies mediating GPCR oligomerization may acutely fine-tune the cellular signaling profile.
Journal ArticleDOI
Temporal reprogramming of calcium signalling via crosstalk of gonadotrophin receptors that associate as functionally asymmetric heteromers.
Kim Jonas,Kim Jonas,S Chen,S Chen,M Virta,J Mora,Stephen Franks,Ilpo Huhtaniemi,Aylin C. Hanyaloglu +8 more
TL;DR: It is demonstrated that gonadotrophin receptor crosstalk alters LH-induced Gαq/11-calcium profiles and proposed that functionally significant FSHR/LHR crosStalk reprograms LH-mediated calcium signalling at the interface of receptor-G protein via formation of asymmetric complexes.
Journal ArticleDOI
Interaction of the periplasmic peptidylprolyl cis-trans isomerase SurA with model peptides. The N-terminal region of SurA id essential and sufficient for peptide binding.
TL;DR: It is proposed that, similar to protein disulfide isomerase and other folding catalysts, SurA exhibits a modular architecture composed of a substrate binding domain and distinct catalytically active domains.
Book ChapterDOI
Di/Oligomerization of GPCRs—Mechanisms and Functional Significance
TL;DR: The evidence for GPCR di/oligomerization at the physiological level is mounting and has begun to shed light on an intricate network of interactions that challenge the previous knowledge on how this family of receptors function.