K
Kimiko Ochiai
Researcher at University of Miyazaki
Publications - 3
Citations - 549
Kimiko Ochiai is an academic researcher from University of Miyazaki. The author has contributed to research in topics: Unfolded protein response & Endoplasmic reticulum. The author has an hindex of 3, co-authored 3 publications receiving 492 citations.
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Journal ArticleDOI
Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation.
Tomohiko Murakami,Atsushi Saito,Shin-ichiro Hino,Shinichi Kondo,Soshi Kanemoto,Kazuyasu Chihara,Hiroshi Sekiya,Kenji Tsumagari,Kimiko Ochiai,Kazuya Yoshinaga,Masahiro Saitoh,Riko Nishimura,Toshiyuki Yoneda,Ikuyo Kou,Tatsuya Furuichi,Shiro Ikegawa,Masahito Ikawa,Masaru Okabe,Akio Wanaka,Kazunori Imaizumi +19 more
TL;DR: The studies show that OASIS is critical for bone formation through the transcription of Col1a1 and the secretion of bone matrix proteins, and they reveal a new mechanism by which ER stress-induced signalling mediates bone formation.
Journal ArticleDOI
Endoplasmic Reticulum Stress Response Mediated by the PERK-eIF2α-ATF4 Pathway Is Involved in Osteoblast Differentiation Induced by BMP2
Atsushi Saito,Kimiko Ochiai,Shinichi Kondo,Kenji Tsumagari,Tomohiko Murakami,Douglas R. Cavener,Kazunori Imaizumi +6 more
TL;DR: In this article, double stranded RNA activated protein kinase (PKR)-like endoplasmic reticulum kinase is a major transducer of the ER stress response and directly phosphorylates eIF2α, resulting in translational attenuation.
Journal ArticleDOI
Effects of the bisphosphonate risedronate on osteopenia in OASIS-deficient mice.
Hiroshi Sekiya,Tomohiko Murakami,Atsushi Saito,Shin-ichiro Hino,Kenji Tsumagari,Kimiko Ochiai,Kazunori Imaizumi +6 more
TL;DR: OASIS−/− mice will be useful as new model mice for evaluating the medicinal effects of osteopenia treatments and developing new drugs for the oste Openia associated with diseases such as OI and osteoporosis, and the abnormal expansion of the rough ER in OASIS+/− osteoblasts was improved by the treatment with RIS.