R
Riko Nishimura
Researcher at Osaka University
Publications - 96
Citations - 6586
Riko Nishimura is an academic researcher from Osaka University. The author has contributed to research in topics: RUNX2 & Osteoblast. The author has an hindex of 41, co-authored 88 publications receiving 5791 citations.
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Journal ArticleDOI
BMP2 Regulates Osterix through Msx2 and Runx2 during Osteoblast Differentiation
Takuma Matsubara,Kumiko Kida,Akira Yamaguchi,Kenji Hata,Fumitaka Ichida,Hiroko Meguro,Hiroyuki Aburatani,Riko Nishimura,Toshiyuki Yoneda +8 more
TL;DR: Osterix is regulated via both Runx2-dependent and -independent mechanisms, and that Osterix controls osteoblast differentiation, at least in part, by regulating the expression of genes not controlled by Runx 2.
Journal ArticleDOI
A bone-seeking clone exhibits different biological properties from the MDA-MB-231 parental human breast cancer cells and a brain-seeking clone in vivo and in vitro.
TL;DR: The data suggest that phenotypic changes allow breast cancer cells to promote osteoclastic bone resorption, survive, and proliferate in bone, which consequently leads to the establishment of bone metastases.
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Critical roles of c-Jun signaling in regulation of NFAT family and RANKL-regulated osteoclast differentiation
Fumiyo Ikeda,Riko Nishimura,Takuma Matsubara,Sakae Tanaka,Jun-ichiro Inoue,Sakamuri V. Reddy,Kenji Hata,Kenji Yamashita,Toru Hiraga,Toshiyuki Watanabe,Toshio Kukita,Katsuji Yoshioka,Anjana Rao,Toshiyuki Yoneda +13 more
TL;DR: Results indicate that c-Jun signaling in cooperation with NFAT is crucial for RANKL-regulated osteoclast differentiation.
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Requirement of BMP-2-induced Phosphatidylinositol 3-Kinase and Akt Serine/Threonine Kinase in Osteoblast Differentiation and Smad-dependent BMP-2 Gene Transcription
Nandini Ghosh-Choudhury,Sherry L. Abboud,Riko Nishimura,Anthony J. Celeste,Lenin Mahimainathan,Goutam Ghosh Choudhury,Goutam Ghosh Choudhury +6 more
TL;DR: Together these data provide the first evidence that activation of BMP receptor serine/threonine kinase stimulates the PI 3 kinase/Akt pathway and define a role for this signal transduction pathway in BMP-specific Smad function during osteoblast differentiation.
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Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation.
Tomohiko Murakami,Atsushi Saito,Shin-ichiro Hino,Shinichi Kondo,Soshi Kanemoto,Kazuyasu Chihara,Hiroshi Sekiya,Kenji Tsumagari,Kimiko Ochiai,Kazuya Yoshinaga,Masahiro Saitoh,Riko Nishimura,Toshiyuki Yoneda,Ikuyo Kou,Tatsuya Furuichi,Shiro Ikegawa,Masahito Ikawa,Masaru Okabe,Akio Wanaka,Kazunori Imaizumi +19 more
TL;DR: The studies show that OASIS is critical for bone formation through the transcription of Col1a1 and the secretion of bone matrix proteins, and they reveal a new mechanism by which ER stress-induced signalling mediates bone formation.