K
Kiran Sonaje
Researcher at National Tsing Hua University
Publications - 25
Citations - 3083
Kiran Sonaje is an academic researcher from National Tsing Hua University. The author has contributed to research in topics: Insulin & Oral administration. The author has an hindex of 18, co-authored 24 publications receiving 2760 citations. Previous affiliations of Kiran Sonaje include University of Lausanne & University of Geneva.
Papers
More filters
Journal ArticleDOI
A review of the prospects for polymeric nanoparticle platforms in oral insulin delivery.
TL;DR: The gastrointestinal barriers to oral insulin delivery, including chemical, enzymatic and absorption barriers, are described and the potential transport mechanisms of insulin delivered by nanoparticles across the intestinal epithelium are discussed.
Journal ArticleDOI
Recent advances in chitosan-based nanoparticles for oral delivery of macromolecules.
Mei Chin Chen,Fwu Long Mi,Zi-Xian Liao,Chun-Wen Hsiao,Kiran Sonaje,Min Fan Chung,Li Wen Hsu,Hsing-Wen Sung +7 more
TL;DR: The synthesis of CS derivatives and their characteristics, as well as their potential transport mechanisms of macromolecular therapeutics across the intestinal biological membrane, are described.
Journal ArticleDOI
In vivo evaluation of safety and efficacy of self-assembled nanoparticles for oral insulin delivery
Kiran Sonaje,Yu Hsin Lin,Yu Hsin Lin,Jyuhn Huarng Juang,Shiaw-Pyng Wey,Chiung-Tong Chen,Hsing-Wen Sung +6 more
TL;DR: Oral administration of insulin-loaded NPs demonstrated a significant hypoglycemic action for at least 10h in diabetic rats and the corresponding relative bioavailability of insulin was found to be 15.1+/-0.9%, suggesting that the NPs prepared in the study are a promising vehicle for oral delivery of insulin.
Journal ArticleDOI
Enteric-coated capsules filled with freeze-dried chitosan/poly(γ-glutamic acid) nanoparticles for oral insulin delivery
Kiran Sonaje,Yi-Jia Chen,Hsin-Lung Chen,Shiaw-Pyng Wey,Jyuhn-Huarng Juang,Ho-Ngoc Nguyen,Chia Wei Hsu,Kun-Ju Lin,Kun-Ju Lin,Hsing-Wen Sung +9 more
TL;DR: The results suggest that the formulation developed in the study might be employed as a potential approach for the oral delivery of insulin and provide a prolonged reduction in blood glucose levels.
Journal ArticleDOI
Opening of epithelial tight junctions and enhancement of paracellular permeation by chitosan: microscopic, ultrastructural, and computed-tomographic observations
Kiran Sonaje,Er-Tuan Chuang,Kun-Ju Lin,Tzu Chen Yen,Fang-Yi Su,Michael T. Tseng,Hsing-Wen Sung +6 more
TL;DR: In vivo fluorescence-microscopic results demonstrate that insulin could be absorbed into the systemic circulation, while most CS was retained in the microvilli scaffolds, and that CS is a safe permeation enhancer and is an effective carrier for oral protein delivery.