A
Adam Orłowski
Researcher at Tampere University of Technology
Publications - 20
Citations - 1321
Adam Orłowski is an academic researcher from Tampere University of Technology. The author has contributed to research in topics: Lipid bilayer & Membrane. The author has an hindex of 14, co-authored 20 publications receiving 1081 citations. Previous affiliations of Adam Orłowski include University of Helsinki & University of Limerick.
Papers
More filters
Journal ArticleDOI
Molecular lipidomics of exosomes released by PC-3 prostate cancer cells.
Alicia Llorente,Tore Skotland,Tore Skotland,Tuulia Sylvänne,Dimple Kauhanen,Tomasz Róg,Adam Orłowski,Ilpo Vattulainen,Ilpo Vattulainen,Kim Ekroos,Kirsten Sandvig,Kirsten Sandvig +11 more
TL;DR: The detailed lipid composition provided in this study may be useful to understand the mechanism of exosome formation, release and function, and several of the lipids enriched in exosomes could potentially be used as cancer biomarkers.
Journal ArticleDOI
Lateral sorting in model membranes by cholesterol-mediated hydrophobic matching
Hermann-Josef Kaiser,Adam Orłowski,Tomasz Róg,Thomas K.M. Nyholm,Wengang Chai,Ten Feizi,Daniel Lingwood,Ilpo Vattulainen,Kai Simons +8 more
TL;DR: In both model membranes and simulations, it is shown that cholesterol critically constrains structural adaptations at the peptide-lipid interface under mismatch, which translates into a sorting potential and lead to selective lateral segregation of peptides and lipids according to their hydrophobic length.
Journal ArticleDOI
N-Glycosylation as determinant of epidermal growth factor receptor conformation in membranes
Karol Kaszuba,Michal Grzybek,Adam Orłowski,Reinis Danne,Tomasz Róg,Kai Simons,Uenal Coskun,Ilpo Vattulainen,Ilpo Vattulainen +8 more
TL;DR: It is found that N-glycosylation is a critical determinant of EGFR conformation, and specifically the orientation of the EGFR ectodomain relative to the membrane, in the absence of a structure for full-length, posttranslationally modified membrane receptors.
Journal ArticleDOI
Study of PEGylated lipid layers as a model for PEGylated liposome surfaces: molecular dynamics simulation and Langmuir monolayer studies.
Michał Stepniewski,Marta Pasenkiewicz-Gierula,Tomasz Róg,Reinis Danne,Adam Orłowski,Mikko Karttunen,Arto Urtti,Marjo Yliperttula,Elina Vuorimaa,Alex Bunker +9 more
TL;DR: The currently accepted picture of the PEG surface layer acting as a generic neutral hydrophilic polymer entirely outside the membrane, with its effect explained through steric interactions, is not sufficient and is thus relevant to nanotechnological drug delivery device design.
Journal ArticleDOI
Interdigitation of long-chain sphingomyelin induces coupling of membrane leaflets in a cholesterol dependent manner.
Tomasz Róg,Adam Orłowski,Alicia Llorente,Tore Skotland,Tuulia Sylvänne,Dimple Kauhanen,Kim Ekroos,Kirsten Sandvig,Ilpo Vattulainen +8 more
TL;DR: This paper uses atomistic molecular dynamics simulations to consider asymmetric lipid membrane models whose compositions are based on the lipidomics data determined for exosomes released by PC-3 prostate cancer cells, and shows interdigitation to be exceptionally strong for long-chain sphingomyelin (SM) molecules.