K
Kirsty E Waddington
Researcher at University College London
Publications - 26
Citations - 593
Kirsty E Waddington is an academic researcher from University College London. The author has contributed to research in topics: Liver X receptor & Membrane lipids. The author has an hindex of 8, co-authored 24 publications receiving 378 citations.
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Journal ArticleDOI
COVID-19-associated hyperinflammation and escalation of patient care: a retrospective longitudinal cohort study.
Jessica J Manson,Colin J Crooks,Meena Naja,Amanda Ledlie,Bethan Goulden,Trevor Liddle,Emon Khan,Puja Mehta,Lucia Martin-Gutierrez,Kirsty E Waddington,George Robinson,Liliana R Santos,Eve McLoughlin,Antonia Snell,Christopher Adeney,Ina Schim van der Loeff,Ina Schim van der Loeff,Kenneth F Baker,Kenneth F Baker,Christopher J A Duncan,Christopher J A Duncan,Aidan T Hanrath,Aidan T Hanrath,B. Clare Lendrem,Anthony De Soyza,Anthony De Soyza,Junjie Peng,Hajar J'bari,Mandy Greenwood,Ellie Hawkins,Hannah Peckham,Michael Marks,Michael Marks,Tommy Rampling,Akish Luintel,Bryan Williams,Michael Brown,Mervyn Singer,Joe West,Elizabeth C. Jury,Matthew Collin,Matthew Collin,Rachel Tattersall +42 more
TL;DR: In this paper, the authors explored a specific phenotype of COVID-19-associated hyperinflammation (COV-HI), and its associations with escalation of respiratory support and survival.
Journal ArticleDOI
Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach
Zuni I. Bassi,Martin Christian Fillmore,Afjal Hussain Miah,Trevor D. Chapman,Claire Maller,Emma J. Roberts,Lauren C. Davis,Darcy E. Lewis,Nicholas Galwey,Kirsty E Waddington,Valentino Parravicini,Abigail L. Macmillan-Jones,Céline Gongora,Philip G. Humphreys,Ian Churcher,Rab K. Prinjha,David F. Tough +16 more
TL;DR: By generating the first PCAF/GCN5 proteolysis targeting chimera (PROTAC), small molecules able to degrade and to potently modulate the expression of multiple inflammatory mediators in LPS-stimulated macrophages and dendritic cells are identified.
Journal ArticleDOI
The nuclear receptor LXR modulates interleukin-18 levels in macrophages through multiple mechanisms.
Benoit Pourcet,Matthew C. Gage,Theresa E. Leon,Kirsty E Waddington,Oscar M. Pello,Knut R. Steffensen,Antonio Castrillo,Annabel F. Valledor,Ines Pineda-Torra +8 more
TL;DR: LXR activation inhibits IL-18 production through regulation of its transcription and maturation into an active pro-inflammatory cytokine, which could be applied to modulate the severity ofIL-18 driven metabolic and inflammatory disorders.
Journal ArticleDOI
Disrupting LXRα phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation
Matthew C. Gage,Bécares-Salles N,R. Louie,Kirsty E Waddington,Y. Zhang,Thais Helena Tittanegro,S. Rodríguez-Lorenzo,A. Jathanna,Benoit Pourcet,Oscar M. Pello,J. V. De la Rosa,J. V. De la Rosa,Antonio Castrillo,Antonio Castrillo,Ines Pineda-Torra +14 more
TL;DR: It is demonstrated that LXRα phosphorylation at S196 is an important determinant of atherosclerotic plaque development through selective changes in gene transcription that affect multiple pathways.
Journal ArticleDOI
Cross-talk between iNKT cells and monocytes triggers an atheroprotective immune response in SLE patients with asymptomatic plaque
Edward J. Smith,Sara Croca,Kirsty E Waddington,Reecha Sofat,Maura Griffin,Andrew N. Nicolaides,Andrew N. Nicolaides,David A. Isenberg,Ines Pineda Torra,Anisur Rahman,Elizabeth C. Jury +10 more
TL;DR: iNKT cell function could link immune responses, lipids, and cardiovascular disease in SLE patients and, together with serum lipid taxonomy, help predict preclinical atherosclerosis in Sle patients.