Kjell-Olov Grönvik

TL;DR: Conditioned media obtained from concanavalin A‐stimulated spleen cell cultures maintain mitogen‐derived T cell blasts in exponential growth for indefinite periods of time, but the appearance of activity in CM is Con A dose‐dependent.

TL;DR: Growth factors contained in Con A‐CM maintain exponential growth in T cell blasts derived from mitogen stimulation of spleen cells with Con A, phytohemagglutinin, lentil lectin and pokeweed mitogen (PWM), as well as from mixed lymphocyte reactions to H‐2 D or I‐E and I‐C‐encoded determinants and from non‐H‐2 Mls locus‐controlled reactions.

TL;DR: The cytokine and the serological data indicated that the Rb1 fraction of ginseng elicits a balanced Th1 and Th2 immune response.

TL;DR: It is shown that TCDD has a long-lasting effect on thymocyte abundance together with a transient effect on cell proliferation, and may also more permanently disturb the normal process of elimination by means of selection.

TL;DR: The effect of TCDD on the specific immune response in vivo was determined by T-cell proliferation and IL-2 production in response to either OVA or anti-mouse-CD3 antibodies plus PMA in vitro, which indicates that even at a high dose of T CDD the intra T- cell signalling pathways in resting cells are not disturbed, but TCDd selectively impairs the antigen-specific activation of T-cells.