Klaus A. Kuhn

TL;DR: Significant efforts of all parties involved in the health care process are needed to improve, implement, and evaluate the concepts described.

TL;DR: The paper uses the clinical domain to motivate and to elaborate the functionality needed to adequately support an advanced application environment and presents solutions for some issues based on the concepts elaborated in the ADEPT project.

TL;DR: Appropriate in silico filtering of exome sequencing data, coupled with functional validation of new disease alleles, is effective in rapidly identifying disease-causative variants in known and new complex I associated disease genes.

TL;DR: The layered approach for system evolution did provide an environment in which a flexible and participatory software development process could be established and will play an increasingly important role to establish responsive IT-infrastructures where the application developer can concentrate on business process alignment instead of coding and debugging.

TL;DR: The data show that collagen type III in vivo may play a crucial role in the initiation of thrombus formation by immunohistochemical technique for the presence of collagen types I, II and III.