K
Klaus Hollmig
Researcher at University of Arkansas for Medical Sciences
Publications - 51
Citations - 5618
Klaus Hollmig is an academic researcher from University of Arkansas for Medical Sciences. The author has contributed to research in topics: Transplantation & Multiple myeloma. The author has an hindex of 22, co-authored 51 publications receiving 5305 citations. Previous affiliations of Klaus Hollmig include Washington University in St. Louis & Fred Hutchinson Cancer Research Center.
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Journal ArticleDOI
The molecular classification of multiple myeloma
Fenghuang Zhan,Yongsheng Huang,Yongsheng Huang,Simona Colla,Simona Colla,James P. Stewart,James P. Stewart,Ichiro Hanamura,Ichiro Hanamura,Sushil K. Gupta,Sushil K. Gupta,Joshua Epstein,Joshua Epstein,Shmuel Yaccoby,Shmuel Yaccoby,Jeffrey R. Sawyer,Jeffrey R. Sawyer,Bart Burington,Bart Burington,Elias Anaissie,Elias Anaissie,Klaus Hollmig,Klaus Hollmig,Mauricio Pineda-Roman,Mauricio Pineda-Roman,Guido J Tricot,Guido J Tricot,Frits van Rhee,Frits van Rhee,Ronald Walker,Ronald Walker,Maurizio Zangari,Maurizio Zangari,John Crowley,John Crowley,Bart Barlogie,Bart Barlogie,John D. Shaughnessy +37 more
TL;DR: A subset of cases with a predominating myeloid gene expression signature had more favorable baseline characteristics and superior prognosis to those lacking this signature, suggesting that this signature is linked to disease progression.
Journal ArticleDOI
A validated gene expression model of high-risk multiple myeloma is defined by deregulated expression of genes mapping to chromosome 1
John D. Shaughnessy,Fenghuang Zhan,Bart Burington,Yongsheng Huang,Simona Colla,Ichiro Hanamura,James P. Stewart,Bob Kordsmeier,Christopher Randolph,David R. Williams,Yan Xiao,Hongwei Xu,Joshua Epstein,Elias Anaissie,Somashekar G. Krishna,Michele Cottler-Fox,Klaus Hollmig,Abid Mohiuddin,Mauricio Pineda-Roman,Guido Tricot,Frits van Rhee,Jeffrey R. Sawyer,Yazan Alsayed,Ronald C. Walker,Maurizio Zangari,John Crowley,Bart Barlogie +26 more
TL;DR: The data suggest that altered transcriptional regulation of genes mapping to chromosome 1 may contribute to disease progression, and that expression profiling can be used to identify high-risk disease and guide therapeutic interventions.
Journal ArticleDOI
Thalidomide and hematopoietic-cell transplantation for multiple myeloma
Bart Barlogie,Guido Tricot,Elias Anaissie,John D. Shaughnessy,Erik Rasmussen,Frits van Rhee,Athanasios Fassas,Maurizio Zangari,Klaus Hollmig,Mauricio Pineda-Roman,Choon Kee Lee,Giampaolo Talamo,Raymond Thertulien,Elias Kiwan,Somashekar G. Krishna,Michele Fox,John Crowley +16 more
TL;DR: When incorporated into high-dose therapy for myeloma, thalidomide increased the frequency of complete responses and extended event-free survival at the expense of added adverse effects without improving overall survival.
Journal ArticleDOI
Frequent gain of chromosome band 1q21 in plasma-cell dyscrasias detected by fluorescence in situ hybridization: incidence increases from MGUS to relapsed myeloma and is related to prognosis and disease progression following tandem stem-cell transplantation.
Ichiro Hanamura,James P. Stewart,James P. Stewart,Yongsheng Huang,Yongsheng Huang,Fenghuang Zhan,Fenghuang Zhan,Madhumita Santra,Madhumita Santra,Jeffrey R. Sawyer,Jeffrey R. Sawyer,Klaus Hollmig,Klaus Hollmig,Maurizio Zangarri,Maurizio Zangarri,Mauricio Pineda-Roman,Mauricio Pineda-Roman,Frits van Rhee,Frits van Rhee,Federica Cavallo,Federica Cavallo,Bart Burington,Bart Burington,John Crowley,John Crowley,Guido J Tricot,Guido J Tricot,Bart Barlogie,Bart Barlogie,John D. Shaughnessy,John D. Shaughnessy +30 more
TL;DR: Investigation of amplification of chromosome band 1q21 in patients with monoclonal gammopathy of undetermined significance, smoldering multiple myeloma, and newly diagnosed MM revealed that Amp1q21 was an independent poor prognostic factor.
Journal ArticleDOI
Magnetic Resonance Imaging in Multiple Myeloma: Diagnostic and Clinical Implications
Ronald C. Walker,Bart Barlogie,Jeffrey Haessler,Guido J Tricot,Elias Anaissie,John D. Shaughnessy,Joshua Epstein,Rudy Van Hemert,Eren Erdem,Antje Hoering,John Crowley,Ernest Ferris,Klaus Hollmig,Frits van Rhee,Maurizio Zangari,Mauricio Pineda-Roman,Abid Mohiuddin,Shmuel Yaccoby,Jeffrey Sawyer,Edgardo J. Angtuaco +19 more
TL;DR: MRI is a more powerful tool for detection of FLs than is MBS and is recommended that, in addition to MBS, MRI be used routinely for staging, prognosis, and response assessment in myeloma.