K
Klaus Lehnert
Researcher at University of Auckland
Publications - 100
Citations - 2437
Klaus Lehnert is an academic researcher from University of Auckland. The author has contributed to research in topics: Medicine & Common variable immunodeficiency. The author has an hindex of 24, co-authored 82 publications receiving 2014 citations. Previous affiliations of Klaus Lehnert include Livestock Improvement Corporation & Hoffmann-La Roche.
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Journal ArticleDOI
Cross-Comparison of Exome Analysis, Next-Generation Sequencing of Amplicons, and the iPLEX® ADME PGx Panel for Pharmacogenomic Profiling
Eng Wee Chua,Eng Wee Chua,Simone L. Cree,Kim N. T. Ton,Klaus Lehnert,Phillip Shepherd,Nuala A. Helsby,Martin A. Kennedy +7 more
TL;DR: Overall, the results have demonstrated WES to be a promising approach for pharmacogenomic profiling, with an estimated error rate of lower than 1%.
Journal ArticleDOI
Haploinsufficiency of the NF-κB1 Subunit p50 in Common Variable Immunodeficiency
Manfred Fliegauf,Vanessa L. Bryant,Vanessa L. Bryant,Natalie Frede,Charlotte A. Slade,Charlotte A. Slade,Charlotte A. Slade,See-Tarn Woon,Klaus Lehnert,Sandra Winzer,Alla Bulashevska,Thomas S. Scerri,Thomas S. Scerri,Euphemia Leung,Anthony Jordan,Baerbel Keller,Esther de Vries,Hongzhi Cao,Fang Yang,Alejandro A. Schäffer,Klaus Warnatz,Peter Browett,Jo A Douglass,Jo A Douglass,Jo A Douglass,Rohan Ameratunga,Jos W. M. van der Meer,Bodo Grimbacher,Bodo Grimbacher +28 more
TL;DR: The CVID phenotype in these families is caused by NF-κB1 p50 haploinsufficiency, with a Dutch-Australian CVID-affected family identified a NFKB1 heterozygous splice-donor-site mutation, causing in-frame skipping of exon 8.
Journal ArticleDOI
Gene transfer of antisense hypoxia inducible factor-1 α enhances the therapeutic efficacy of cancer immunotherapy
Xueying Sun,Jagat R. Kanwar,Euphemia Leung,Klaus Lehnert,Dongmao Wang,Geoffrey W. Krissansen +5 more
TL;DR: The results herein indicate that blocking hypoxia-inducible pathways and enhancing NK-mediated antitumor immunity by targeting HIF-1 itself may be advantageous, especially when combined with cancer immunotherapy.
Journal ArticleDOI
Modulation of the maternal immune system by the pre-implantation embryo
Caroline G. Walker,Susanne Meier,Mathew D Littlejohn,Klaus Lehnert,John R Roche,Murray D. Mitchell,Murray D. Mitchell +6 more
TL;DR: In this paper, genome-wide transcriptional profiles of reproductive day 17 endometrial tissue were determined in pregnant and cyclic Holstein-Friesian dairy cattle, and they revealed enrichment for genes involved in interferon signalling and modulation of the immune response in pregnant animals.
Journal ArticleDOI
Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition.
Mathew D Littlejohn,Mathew D Littlejohn,Kathryn Tiplady,Tania Fink,Klaus Lehnert,Thomas Lopdell,Thomas Johnson,Christine Couldrey,M. Keehan,Richard G. Sherlock,Chad Harland,Andrew D Scott,Russell G. Snell,Stephen R. Davis,Richard J. Spelman +14 more
TL;DR: Genome sequence-based imputation and association mapping in a population of 64,244 taurine cattle reveals a cluster of 17 non-coding variants spanning MGST1 that are highly associated with milk fat percentage, and a range of other milk composition traits, and implicate MG ST1, a gene with no obvious mechanistic relationship to milk composition regulation, as causally involved in these processes.