K
Klaus Pfizenmaier
Researcher at University of Stuttgart
Publications - 180
Citations - 17743
Klaus Pfizenmaier is an academic researcher from University of Stuttgart. The author has contributed to research in topics: Tumor necrosis factor alpha & Cytotoxic T cell. The author has an hindex of 68, co-authored 176 publications receiving 16750 citations.
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Journal ArticleDOI
Tumor necrosis factor signaling.
TL;DR: Some general aspects of this fascinating molecule are covered and then the molecular mechanisms of TNF signal transduction will be addressed, including the multiple facets of crosstalk between the various signalling pathways engaged by TNF.
Journal ArticleDOI
The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kda tumor necrosis factor receptor
Matthias Grell,Eleni Douni,Harald Wajant,Matthias Löhden,Matthias Clauss,Beate Maxeiner,Spiros Georgopoulos,Werner Lesslauer,George Kollias,Klaus Pfizenmaier,Peter Scheurich +10 more
TL;DR: It is shown here that the transmembrane form of TNF is superior to soluble TNF in activating TNFR80 in activating TNF-induced cellular responses in various systems such as T cell activation, thymocyte proliferation, and granulocyte/macrophage colony-stimulating factor production.
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Neurodegenerative and neuroprotective effects of tumor Necrosis factor (TNF) in retinal ischemia: opposite roles of TNF receptor 1 and TNF receptor 2.
Valérie Fontaine,Saddek Mohand-Said,Noelle Hanoteau,Céline Fuchs,Klaus Pfizenmaier,Ulrich L. M. Eisel +5 more
TL;DR: Early, transient upregulation of TNF, TNF receptor 1, and TNF-R1 6 hr after reperfusion preceding neuronal cell loss in retinal ischemia is shown, indicating an instrumental role of Akt/PKB in neuroprotection and T NF-R2 dependence of this pathway.
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PKCu is a novel, atypical member of the protein kinase C family.
TL;DR: The lack of the C2 domain of the Ca(2+)-dependent PKCs and the presence of a unique NH2-terminal sequence with a potential signal peptide and a transmembrane domain suggest that PKC mu is a novel member of the subgroup of atypical PKCs.
Journal Article
Neurodegenerative and neuroprotective effects of tumor necrosis factor (TNF) in retinal ischemia
TL;DR: In this article, the authors compared ischemia-reperfusion-induced retinal damage in mice deficient for TNF, TNF-R1, or TNF by quantifying neuronal cell loss 8 d after the insult.