K
Koen Van Laer
Researcher at German Cancer Research Center
Publications - 16
Citations - 990
Koen Van Laer is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Mycothiol & Cysteine. The author has an hindex of 12, co-authored 15 publications receiving 812 citations. Previous affiliations of Koen Van Laer include Vrije Universiteit Brussel & Flanders Institute for Biotechnology.
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Journal ArticleDOI
Real-time monitoring of basal H2O2 levels with peroxiredoxin-based probes.
Bruce A. Morgan,Bruce A. Morgan,Koen Van Laer,Theresa N E Owusu,Daria Ezeriņa,Daniel Pastor-Flores,Prince Saforo Amponsah,Anja Tursch,Tobias P. Dick +8 more
TL;DR: The roGFP2-Tsa2ΔCR probe revealed real-time interplay between basal H2O2 levels and partial oxygen pressure and exposed asymmetry in H 2O2 trafficking between the cytosol and mitochondrial matrix and a strong correlation between matrix H1N1 levels and cellular growth rate.
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A proton relay enhances H2O2 sensitivity of GAPDH to facilitate metabolic adaptation.
David Peralta,Agnieszka K. Bronowska,Bruce A. Morgan,Éva Dóka,Koen Van Laer,Péter Nagy,Frauke Gräter,Tobias P. Dick +7 more
TL;DR: It is shown that H2O2 reactivity of the active site thiolate (C152) is catalyzed by a previously unrecognized mechanism based on a dedicated proton relay promoting leaving group departure, which is a key component of the cellular adaptive response to increased H 2O2 levels.
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The Conundrum of Hydrogen Peroxide Signaling and the Emerging Role of Peroxiredoxins as Redox Relay Hubs.
TL;DR: This work has shown that Prxs are exceptionally sensitive to H2O2, abundantly expressed and capture most of the H 2O2 that is generated inside cells, and their mechanism, structural organization, and the potential role of adaptor proteins are still unknown.
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Low-Molecular-Weight Thiols in Thiol–Disulfide Exchange
TL;DR: The fundamental biophysical properties, thiol pK(a) and redox potential, have not yet been determined, and the protein interactome in which the biothiols MSH and BSH are involved needs further exploration.
Journal ArticleDOI
Mycoredoxin-1 is one of the missing links in the oxidative stress defence mechanism of Mycobacteria.
Koen Van Laer,Lieven Buts,Lieven Buts,Nicolas Foloppe,Didier Vertommen,Karolien Van Belle,Karolien Van Belle,Khadija Wahni,Khadija Wahni,Goedele Roos,Lennart Nilsson,Luis M. Mateos,Mamta Rawat,Nico A. J. van Nuland,Nico A. J. van Nuland,Joris Messens,Joris Messens +16 more
TL;DR: Determination of the oxidized and reduced structures of mycoredoxin‐1, better understanding of the mycothiol‐dependent reactions in general, will likely give new insights in how M. tuberculosis survives oxidative stress in human macrophages.