Koichi Takebayashi

TL;DR: Transient transfection assays using C3H10T1/2 cells suggest that there are several positive regulatory regions in the HES-1 gene, however, cotransfection of the H ES-1 expression vector leads to approximately 40-fold repression in promoter activity, which raises the possibility that Hes1 gene expression may be negatively autoregulated through the N box sequences.

TL;DR: The basic helix-loop-helix (bHLH) factor Mash1 regulates brain and eye morphogenesis by inhibiting premature neuronal differentiation, and the down-regulation of HES1 expression at the right time is required for normal development of the nervous system.

TL;DR: Evidence is provided that ATH‐3 can directly convert non‐neural or undetermined cells into a neural fate, and it is suggested that the Ser residue in the basic region may be critical for the regulation of A TH‐3 activity by phosphorylation.

TL;DR: Promoter analysis shows that this undifferentiated neural-specific expression is mediated by the multiple GC stretches present in the HES-5 promoter, and Gel mobility shift analysis suggests the presence of a neural precursor cell-specific protein that binds to the GC stretches.

TL;DR: Molecular aspect of mammalian neurogenesis of mammalian HLH factors expressed in the nervous system is discussed and the balance between them is important for the developmental processes.