K
Koichiro Kuwahara
Researcher at Shinshu University
Publications - 264
Citations - 8167
Koichiro Kuwahara is an academic researcher from Shinshu University. The author has contributed to research in topics: Heart failure & Medicine. The author has an hindex of 46, co-authored 218 publications receiving 7050 citations. Previous affiliations of Koichiro Kuwahara include Kyoto University & Kumamoto University.
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Journal ArticleDOI
Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension
Yoshihiro Miyamoto,Yoshihiko Saito,Noboru Kajiyama,Michihiro Yoshimura,Yukio Shimasaki,Masafumi Nakayama,Shigeki Kamitani,Masaki Harada,Masahiro Ishikawa,Koichiro Kuwahara,Emiko Ogawa,Ichiro Hamanaka,Nobuki Takahashi,Toshihiko Kaneshige,Hiroshi Teraoka,Takashi Akamizu,Nobuyuki Azuma,Yasunao Yoshimasa,Takaaki Yoshimasa,Hiroshi Itoh,Izuru Masuda,Hirofumi Yasue,Kazuwa Nakao +22 more
TL;DR: A missense variant, Glu298Asp, in exon 7 of the eNOS gene is identified and demonstrated that it is associated with both coronary spastic angina and myocardial infarction, which suggests thatIt is a genetic susceptibility factor for essential hypertension.
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TRPC6 fulfills a calcineurin signaling circuit during pathologic cardiac remodeling
Koichiro Kuwahara,Yanggan Wang,John McAnally,James A. Richardson,Rhonda S Bassel-Duby,Joseph A. Hill,Eric N. Olson +6 more
TL;DR: Cardiac-specific overexpression of TRPC6 in transgenic mice resulted in heightened sensitivity to stress, a propensity for lethal cardiac growth and heart failure, and an increase in NFAT-dependent expression of beta-myosin heavy chain, a sensitive marker for pathologic hypertrophy.
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Myocardin-Related Transcription Factor-A Controls Myofibroblast Activation and Fibrosis in Response to Myocardial Infarction
Eric M. Small,Jeffrey E. Thatcher,Lillian B. Sutherland,Hideyuki Kinoshita,Robert D. Gerard,James A. Richardson,J. Michael DiMaio,Hesham A. Sadek,Koichiro Kuwahara,Eric N. Olson +9 more
TL;DR: It is concluded that MRTF-A regulates myofibroblast activation and fibrosis in response to the renin–angiotensin system and post-MI remodeling.
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Significance of Ventricular Myocytes and Nonmyocytes Interaction During Cardiocyte Hypertrophy Evidence for Endothelin-1 as a Paracrine Hypertrophic Factor From Cardiac Nonmyocytes
Masaki Harada,Hiroshi Itoh,Osamu Nakagawa,Yoshihiro Ogawa,Yoshihiro Miyamoto,Koichiro Kuwahara,Emiko Ogawa,Toshio Igaki,Jun K. Yamashita,Izuru Masuda,Takaaki Yoshimasa,Issei Tanaka,Yoshihiko Saito,Kazuwa Nakao +13 more
TL;DR: It is demonstrated that N MCs regulate MC hypertrophy at least partially via ET-1 secretion and that the interaction between MCs and NMCs plays a critical role during the process of Ang II- or TGF-beta1-induced cardiocyte hypertrotrophy.
Journal ArticleDOI
Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-->C mutation associated with coronary spastic angina.
Yoshihiro Miyamoto,Yoshihiko Saito,Masafumi Nakayama,Yukio Shimasaki,Toshihiro Yoshimura,Michihiro Yoshimura,Masaki Harada,Noboru Kajiyama,Ichiro Kishimoto,Koichiro Kuwahara,Jun Hino,Emiko Ogawa,Ichiro Hamanaka,Shigeki Kamitani,Nobuki Takahashi,Rika Kawakami,Kenji Kangawa,Hirofumi Yasue,Kazuwa Nakao +18 more
TL;DR: RPA1 apparently functions as a repressor protein in the -786T-->C mutation-related reduction of eNOS gene transcription associated with the development of coronary artery disease.