N
Nobuki Takahashi
Researcher at Kyoto University
Publications - 30
Citations - 2620
Nobuki Takahashi is an academic researcher from Kyoto University. The author has contributed to research in topics: Brain natriuretic peptide & Cardiotrophin 1. The author has an hindex of 25, co-authored 30 publications receiving 2519 citations. Previous affiliations of Nobuki Takahashi include Kumamoto University & Nara Medical University.
Papers
More filters
Journal ArticleDOI
Endothelial Nitric Oxide Synthase Gene Is Positively Associated With Essential Hypertension
Yoshihiro Miyamoto,Yoshihiko Saito,Noboru Kajiyama,Michihiro Yoshimura,Yukio Shimasaki,Masafumi Nakayama,Shigeki Kamitani,Masaki Harada,Masahiro Ishikawa,Koichiro Kuwahara,Emiko Ogawa,Ichiro Hamanaka,Nobuki Takahashi,Toshihiko Kaneshige,Hiroshi Teraoka,Takashi Akamizu,Nobuyuki Azuma,Yasunao Yoshimasa,Takaaki Yoshimasa,Hiroshi Itoh,Izuru Masuda,Hirofumi Yasue,Kazuwa Nakao +22 more
TL;DR: A missense variant, Glu298Asp, in exon 7 of the eNOS gene is identified and demonstrated that it is associated with both coronary spastic angina and myocardial infarction, which suggests thatIt is a genetic susceptibility factor for essential hypertension.
Journal ArticleDOI
Replication protein A1 reduces transcription of the endothelial nitric oxide synthase gene containing a -786T-->C mutation associated with coronary spastic angina.
Yoshihiro Miyamoto,Yoshihiko Saito,Masafumi Nakayama,Yukio Shimasaki,Toshihiro Yoshimura,Michihiro Yoshimura,Masaki Harada,Noboru Kajiyama,Ichiro Kishimoto,Koichiro Kuwahara,Jun Hino,Emiko Ogawa,Ichiro Hamanaka,Shigeki Kamitani,Nobuki Takahashi,Rika Kawakami,Kenji Kangawa,Hirofumi Yasue,Kazuwa Nakao +18 more
TL;DR: RPA1 apparently functions as a repressor protein in the -786T-->C mutation-related reduction of eNOS gene transcription associated with the development of coronary artery disease.
Journal ArticleDOI
NRSF regulates the fetal cardiac gene program and maintains normal cardiac structure and function
Koichiro Kuwahara,Yoshihiko Saito,Makoto Takano,Yuji Arai,Shinji Yasuno,Yasuaki Nakagawa,Nobuki Takahashi,Yuichiro Adachi,Genzo Takemura,Minoru Horie,Yoshihiro Miyamoto,Takayuki Morisaki,Shinobu Kuratomi,Akinori Noma,Hisayoshi Fujiwara,Yasunao Yoshimasa,Hideyuki Kinoshita,Rika Kawakami,Ichiro Kishimoto,Michio Nakanishi,Satoru Usami,Y. Saito,Masaki Harada,Kazuwa Nakao +23 more
TL;DR: It is demonstrated that genes encoding two ion channels that carry the fetal cardiac currents If and ICa,T, which are induced in these mice and are potentially responsible for both the cardiac dysfunction and the arrhythmogenesis, are regulated by NRSF.
Journal ArticleDOI
Cardiotrophin-1 phosphorylates akt and BAD, and prolongs cell survival via a PI3K-dependent pathway in cardiac myocytes.
Koichiro Kuwahara,Yoshihiko Saito,Ichiro Kishimoto,Yoshihiro Miyamoto,Masaki Harada,Emiko Ogawa,Ichiro Hamanaka,Noboru Kajiyama,Nobuki Takahashi,Takehiko Izumi,Rika Kawakami,Kazuwa Nakao +11 more
TL;DR: Findings show that PI3K-dependent survival signals contribute to CT-1-mediated ventricular myocyte survival and prolonged the survival of serum-starved ventricularMyocytes by preventing apoptosis.
Journal ArticleDOI
The effects of the selective ROCK inhibitor, Y27632, on ET-1-induced hypertrophic response in neonatal rat cardiac myocytes - Possible involvement of Rho/ROCK pathway in cardiac muscle cell hypertrophy
Koichiro Kuwahara,Yoshihiko Saito,Osamu Nakagawa,Ichiro Kishimoto,Masaki Harada,Emiko Ogawa,Yoshihiro Miyamoto,Ichiro Hamanaka,Noboru Kajiyama,Nobuki Takahashi,Takehiko Izumi,Rika Kawakami,Naohisa Tamura,Yoshihiro Ogawa,Kazuwa Nakao +14 more
TL;DR: Findings suggest that the Rho/ROCK pathway is an important component of ET‐1‐induced hypertrophic signals in cardiac myocytes.