K
Kosuke Chayama
Researcher at Anschutz Medical Campus
Publications - 3
Citations - 286
Kosuke Chayama is an academic researcher from Anschutz Medical Campus. The author has contributed to research in topics: MAP kinase kinase kinase & Kinase. The author has an hindex of 3, co-authored 3 publications receiving 279 citations.
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Journal Article
Mitogen-activated protein kinase activation through Fc epsilon receptor I and stem cell factor receptor is differentially regulated by phosphatidylinositol 3-kinase and calcineurin in mouse bone marrow-derived mast cells.
Tamotsu Ishizuka,Kosuke Chayama,Katsuyuki Takeda,Eckard Hamelmann,Naohiro Terada,Gordon Keller,Gary L. Johnson,Erwin W. Gelfand +7 more
TL;DR: Results indicate that both PI3-kinase and calcineurin may contribute to the regulation of cytokine gene transcription and the degranulation response by modulating JNK activity in BMMC.
Journal ArticleDOI
MEKK2 gene disruption causes loss of cytokine production in response to IgE and c-Kit ligand stimulation of ES cell-derived mast cells
Timothy P. Garrington,Tamotsu Ishizuka,Philip J. Papst,Kosuke Chayama,Saiphone Webb,Toshiaki Yujiri,Weiyong Sun,Sue Sather,David M. Russell,Spencer B. Gibson,Gordon Keller,Erwin W. Gelfand,Gary L. Johnson +12 more
TL;DR: MEKK2 is the first MAP3K shown to be required for mast cell tyrosine kinase receptor signaling controlling cytokine gene expression, and JNK activation in response to UV irradiation was normal, showing that MEK2 is required for receptor signaling but not for cellular stress responses.
Journal ArticleDOI
Role of MEKK2-MEK5 in the regulation of TNF-α gene expression and MEKK2-MKK7 in the activation of c-Jun N-terminal kinase in mast cells
Kosuke Chayama,Philip J. Papst,Timothy P. Garrington,Joanne C. Pratt,Tamotsu Ishizuka,Saiphone Webb,Soula Ganiatsas,Leonard I. Zon,Weiyong Sun,Gary L. Johnson,Erwin W. Gelfand +10 more
TL;DR: It is suggested that JNK activation by antigen cross-linking is dependent on the MEKK2-MKK7 pathway, and cytokine production in mast cells is regulated in part by the signaling complex MEKK 2-MEK5-ERK5.