K
Kota Arima
Researcher at Kumamoto University
Publications - 84
Citations - 1387
Kota Arima is an academic researcher from Kumamoto University. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 18, co-authored 74 publications receiving 894 citations.
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Journal ArticleDOI
Activation of Transforming Growth Factor Beta 1 Signaling in Gastric Cancer-associated Fibroblasts Increases Their Motility, via Expression of Rhomboid 5 Homolog 2, and Ability to Induce Invasiveness of Gastric Cancer Cells
Takatsugu Ishimoto,Takatsugu Ishimoto,Keisuke Miyake,Tannistha Nandi,Masakazu Yashiro,Nobuyuki Onishi,Kie Kyon Huang,Suling Joyce Lin,Ramnarayanan Kalpana,Su Ting Tay,Yuka Suzuki,Byoung Chul Cho,Daisuke Kuroda,Kota Arima,Daisuke Izumi,Masaaki Iwatsuki,Yoshifumi Baba,Eiji Oki,Masayuki Watanabe,Hideyuki Saya,Kosei Hirakawa,Hideo Baba,Patrick Tan,Patrick Tan +23 more
TL;DR: Many of the genes with increased expression in CAFs compared with NFs were associated with transforming growth factor beta 1 (TGFB1) activity, and RHBDF2 appeared to regulate oncogenic and non-canonical TGFB 1 signaling.
Journal ArticleDOI
Tumour-infiltrating inflammatory and immune cells in patients with extrahepatic cholangiocarcinoma.
Yuki Kitano,Hirohisa Okabe,Yo-ichi Yamashita,Shigeki Nakagawa,Yoichi Saito,Naoki Umezaki,Masayo Tsukamoto,Takanobu Yamao,Kensuke Yamamura,Kota Arima,Takayoshi Kaida,Tatsunori Miyata,Kosuke Mima,Katsunori Imai,Daisuke Hashimoto,Yoshihiro Komohara,Akira Chikamoto,Takatoshi Ishiko,Hideo Baba +18 more
TL;DR: The data showed that tumour infiltrating inflammatory and immune cells may play a pivotal role in ECC progression and a high-risk signature predicted poor prognosis in E CC patients.
Journal ArticleDOI
miR-9-3p plays a tumour-suppressor role by targeting TAZ (WWTR1) in hepatocellular carcinoma cells.
Takaaki Higashi,H. Hayashi,Takatsugu Ishimoto,Hideaki Takeyama,Takayoshi Kaida,Kota Arima,K Taki,Kiyoshi Sakamoto,Hideyuki Kuroki,Hirohisa Okabe,Hidetoshi Nitta,Daisuke Hashimoto,Akira Chikamoto,T. Beppu,Hideo Baba +14 more
TL;DR: MicroRNA-9-3p was identified as the tumour-suppressor miR targetting TAZ expression in HCC cells and there was the inverse correlation between miR- 9-3P and TAZ expressions.
Journal ArticleDOI
Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance
Tomoyuki Uchihara,Keisuke Miyake,Atsuko Yonemura,Yoshihiro Komohara,Rumi Itoyama,Mayu Koiwa,Tadahito Yasuda,Kota Arima,Kazuto Harada,Kazuto Harada,Kojiro Eto,Hiromitsu Hayashi,Masaaki Iwatsuki,Shiro Iwagami,Yoshifumi Baba,Naoya Yoshida,Masakazu Yashiro,Mari Masuda,Jaffer A. Ajani,Patrick Tan,Hideo Baba,Takatsugu Ishimoto +21 more
TL;DR: It is demonstrated that drug resistance is conferred by Annexin A6 in CAF-EV and provide a potential avenue for overcoming gastric cancer drug resistance through the inhibition of FAK-YAP signaling in combination with conventional chemotherapeutics.
Journal ArticleDOI
Effects of Preoperative Neutrophil-to-Lymphocyte and Platelet-to-Lymphocyte Ratios on Survival in Patients with Extrahepatic Cholangiocarcinoma.
Yuki Kitano,Yo-ichi Yamashita,Kensuke Yamamura,Kota Arima,Takayoshi Kaida,Tatsunori Miyata,Shigeki Nakagawa,Kosuke Mima,Katsunori Imai,Daisuke Hashimoto,Akira Chikamoto,Hideo Baba +11 more
TL;DR: High preoperative PLR was an independent predictor of poor prognosis for patients with ECC who underwent resections as well as independent prognostic factors for OS.