Kouji Kobiyama

TL;DR: It is shown that the Atg5–Atg12 conjugate, a key regulator of the autophagic process, plays an important role in innate antiviral immune responses, thereby contributing to RNA virus replication in host cells.

TL;DR: The finding that host DNA released from dying cells acts as a damage-associated molecular pattern that mediates alum adjuvant activity may increase the understanding of the mechanisms of action of current vaccines and help in the design of new adjuvants.

TL;DR: In this paper , the effective reproduction number of BA.2 is 1.4 times higher than BA.1.1 spike-bearing virus in multiple countries, such as Denmark and the UK.

TL;DR: In this article, the authors show that TPT-treated cancer cells release exosomes that contain DNA that activate dendritic cells via STING signaling, and that a STING-dependent pathway drives antitumor immunity by responding to tumor cell-derived DNA.

TL;DR: It is shown that treatment of breast cancer cells with the antitumor agent topotecan (TPT), an inhibitor of topoisomerase I, induces danger-associated molecular pattern secretion that triggers dendritic cell activation and cytokine production, suggesting that a STING-dependent pathway drives antitumors immunity by responding to tumor cell–derived DNA.