K
Krista G. Haanstra
Researcher at Biomedical Primate Research Centre
Publications - 38
Citations - 1031
Krista G. Haanstra is an academic researcher from Biomedical Primate Research Centre. The author has contributed to research in topics: Transplantation & Experimental autoimmune encephalomyelitis. The author has an hindex of 16, co-authored 38 publications receiving 876 citations.
Papers
More filters
Journal ArticleDOI
Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques.
Karin Dijkman,Claudia C. Sombroek,Richard A. W. Vervenne,Sam O. Hofman,Charelle Boot,Edmond J. Remarque,Clemens H. M. Kocken,Tom H. M. Ottenhoff,Ivanela Kondova,Mohammed A. Khayum,Krista G. Haanstra,Michel P.M. Vierboom,Frank A. W. Verreck +12 more
TL;DR: It is shown that pulmonary BCG prevents infection by using a repeated limiting-dose Mycobacterium tuberculosis challenge model and polyfunctional T-helper type 17 (TH17) cells, interleukin-10 and immunoglobulin A as correlates of local protective immunity.
Journal ArticleDOI
Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates.
Krista G. Haanstra,Jan Ringers,Ella A. Sick,Seema Ramdien-Murli,Eva-Maria Kuhn,Louis Boon,Margreet Jonker +6 more
TL;DR: Blocking costimulation by anti-CD40 or by anti -CD40 plusAnti-CD86 plus anti- CD86 may be an effective method to prevent graft rejection and may obviate the need for other immunosuppressive drugs, especially in the immediate posttransplantation period.
Journal ArticleDOI
Antagonizing the α4β1 Integrin, but Not α4β7, Inhibits Leukocytic Infiltration of the Central Nervous System in Rhesus Monkey Experimental Autoimmune Encephalomyelitis
Krista G. Haanstra,Sam O. Hofman,Dave M. Lopes Estevao,Erwin L. A. Blezer,Jan Bauer,Li-Li Yang,Tim Wyant,Vilmos Csizmadia,Bert A. 't Hart,Eric R. Fedyk +9 more
TL;DR: It is demonstrated that blocking α4β7 exclusively does not inhibit immune surveillance of the CNS in primates.
Journal ArticleDOI
Expression of IL-1β in rhesus EAE and MS lesions is mainly induced in the CNS itself.
Saskia M. Burm,Laura A. N. Peferoen,Ella A. Zuiderwijk-Sick,Krista G. Haanstra,Bert A. 't Hart,Paul van der Valk,Sandra Amor,Jan Bauer,Jeffrey J. Bajramovic +8 more
TL;DR: Although the exact localization and relative intensity of IL-1β expression in EAE and MS is different, the staining pattern in both neuroinflammatory disorders is most consistent with the idea that the expression of IL -1β during lesion development is induced in the tissue rather than in the periphery.
Journal ArticleDOI
Costimulation blockade followed by a 12-week period of cyclosporine A facilitates prolonged drug-free survival of rhesus monkey kidney allografts.
Krista G. Haanstra,Ella A. Sick,Jan Ringers,Jacqueline Wubben,Eva-Maria Kuhn,Louis Boon,Margreet Jonker +6 more
TL;DR: An induction therapy using antagonistic antibodies against CD40 and CD86 is reported, followed by a delayed 12-week course of low-dose cyclosporine A (CsA) treatment in the rhesus monkey kidney-allograft model, which resulted in more than 3-year drug-free survival in two of four animals.