F
Frank A. W. Verreck
Researcher at Biomedical Primate Research Centre
Publications - 67
Citations - 5579
Frank A. W. Verreck is an academic researcher from Biomedical Primate Research Centre. The author has contributed to research in topics: Tuberculosis & Vaccination. The author has an hindex of 32, co-authored 64 publications receiving 4914 citations. Previous affiliations of Frank A. W. Verreck include Leiden University Medical Center & Leiden University.
Papers
More filters
Journal ArticleDOI
Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy
Eric Reits,James W. Hodge,Carla A. Herberts,Tom A.M. Groothuis,Mala Chakraborty,Elizabeth K. Wansley,Kevin Camphausen,Rosalie M. Luiten,Arnold H. de Ru,Joost Neijssen,Alexander Griekspoor,Elly Mesman,Frank A. W. Verreck,Hergen Spits,Jeffrey Schlom,Peter A. van Veelen,Jacques Neefjes +16 more
TL;DR: In this paper, the effect of irradiation on antigen presentation by MHC class I molecules was studied and it was shown that immunotherapy is successful in eradicating a murine colon adenocarcinoma only when preceded by radiotherapy of the tumor tissue.
Journal ArticleDOI
Human IL-23-producing type 1 macrophages promote but IL-10-producing type 2 macrophages subvert immunity to (myco)bacteria
Frank A. W. Verreck,Tjitske de Boer,Dennis M. L. Langenberg,Marieke A. Hoeve,Matthijs Kramer,Elena Vaisberg,Robert A. Kastelein,Arend J. Kolk,Rene de Waal-Malefyt,Tom H. M. Ottenhoff +9 more
TL;DR: IL-23 rather than IL-12 is the primary type 1 cytokine produced by activated proinflammatory Mphi-1, indicating that Mphi heterogeneity thus may be an important determinant of immunity and disease outcome in intracellular bacterial infection.
Journal ArticleDOI
Phenotypic and functional profiling of human proinflammatory type-1 and anti-inflammatory type-2 macrophages in response to microbial antigens and IFN-gamma- and CD40L-mediated costimulation.
Frank A. W. Verreck,Tjitske de Boer,Dennis M. L. Langenberg,Linda van der Zanden,Tom H. M. Ottenhoff +4 more
TL;DR: It is remarkable that Mφ‐2 secreted high levels of IL‐8, MCP‐1, IP‐10, MIP‐1β, and RANTES, suggesting an active role for these cells in regulating cellular immunity and homeostasis, and demonstrates how M φ‐1/M⩽2 polarization can differentially skew the host response toward pro‐ or anti‐inflammatory immune responses, respectively.
Journal ArticleDOI
Genetics, cytokines and human infectious disease: lessons from weakly pathogenic mycobacteria and salmonellae.
Tom H. M. Ottenhoff,Frank A. W. Verreck,Elgin G. R. Lichtenauer-Kaligis,Marieke A. Hoeve,Ozden Sanal,Jaap T. van Dissel +5 more
TL;DR: Host genetic factors are important in determining the outcome of infections caused by intracellular pathogens, including mycobacteria and salmonellae, but until now have been poorly characterized.
Journal ArticleDOI
Divergent effects of IL-12 and IL-23 on the production of IL-17 by human T cells.
Marieke A. Hoeve,Marieke A. Hoeve,Nigel D. L. Savage,Tjitske de Boer,Dennis M. L. Langenberg,Rene De Waal Malefyt,Tom H. M. Ottenhoff,Frank A. W. Verreck +7 more
TL;DR: The roles of exogenous (recombinant) and endogenous (macrophage‐derived) IL‐12 and IL‐23, on IL‐17‐induction in human T‐cells are investigated to provide novel insights into the regulation of immunity, inflammation and immunopathology.