R
Richard A. W. Vervenne
Researcher at Biomedical Primate Research Centre
Publications - 23
Citations - 1400
Richard A. W. Vervenne is an academic researcher from Biomedical Primate Research Centre. The author has contributed to research in topics: Vaccination & Tuberculosis. The author has an hindex of 13, co-authored 23 publications receiving 1216 citations.
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Journal ArticleDOI
Protection of macaques against Mycobacterium tuberculosis infection by a subunit vaccine based on a fusion protein of antigen 85B and ESAT-6.
Jan A.M. Langermans,T. Mark Doherty,Richard A. W. Vervenne,Tridia van der Laan,Konstantin P. Lyashchenko,Rena Greenwald,Else Marie Agger,Claus Aagaard,H. Weiler,Dick van Soolingen,Wilfried Dalemans,Alan W. Thomas,Peter Andersen +12 more
TL;DR: It is shown, in two independent experiments, that vaccination of primates with Ag85B-ESAT-6 induces protective immune responses, suggesting that Ag85 B-ESat-6 is a strong candidate for further clinical evaluation.
Journal ArticleDOI
MVA.85A boosting of BCG and an attenuated, phoP deficient M. tuberculosis vaccine both show protective efficacy against tuberculosis in rhesus macaques.
Frank A. W. Verreck,Richard A. W. Vervenne,Ivanela Kondova,Klaas W. van Kralingen,Edmond J. Remarque,Gerco Braskamp,Nicole van der Werff,Ariena Kersbergen,Tom H. M. Ottenhoff,Peter J. Heidt,Sarah C. Gilbert,Brigitte Gicquel,Adrian V. S. Hill,Carlos Martin,Helen McShane,Alan W. Thomas +15 more
TL;DR: Both the BCG/MVA.85A prime-boost regime and the novel live attenuated, phoP deficient TB vaccine candidate SO2 showed significant protective efficacy by various parameters in rhesus macaques, which support further development of these primary and combination TB vaccine candidates.
Journal ArticleDOI
Divergent effect of bacillus Calmette–Guérin (BCG) vaccination on Mycobacterium tuberculosis infection in highly related macaque species: Implications for primate models in tuberculosis vaccine research
Jan A.M. Langermans,Peter Andersen,Dick van Soolingen,Richard A. W. Vervenne,Patrice A. Frost,Tridia van der Laan,Laurens A. H. van Pinxteren,Jan van den Hombergh,Saskia Kroon,Inge Peekel,Sandrine Florquin,Alan W. Thomas +11 more
TL;DR: In this paper, the authors compared the efficacy of Bacillus Calmette-Guerin vaccination and the course of infection in rhesus and cynomolgus monkeys.
Journal ArticleDOI
Prevention of tuberculosis infection and disease by local BCG in repeatedly exposed rhesus macaques.
Karin Dijkman,Claudia C. Sombroek,Richard A. W. Vervenne,Sam O. Hofman,Charelle Boot,Edmond J. Remarque,Clemens H. M. Kocken,Tom H. M. Ottenhoff,Ivanela Kondova,Mohammed A. Khayum,Krista G. Haanstra,Michel P.M. Vierboom,Frank A. W. Verreck +12 more
TL;DR: It is shown that pulmonary BCG prevents infection by using a repeated limiting-dose Mycobacterium tuberculosis challenge model and polyfunctional T-helper type 17 (TH17) cells, interleukin-10 and immunoglobulin A as correlates of local protective immunity.
Journal ArticleDOI
Antibodies to Glycans Dominate the Host Response to Schistosome Larvae and Eggs: Is Their Role Protective or Subversive?
Matthias Eberl,Jan A.M. Langermans,Richard A. W. Vervenne,A. Kwame Nyame,Richard D. Cummings,Alan W. Thomas,Patricia S. Coulson,R. Alan Wilson +7 more
TL;DR: The antiglycan responses resulting from infection could be a smoke screen to subvert the immune system away from more vulnerable larval peptide epitopes, and explain the long time required for antischistosome immunity to build up after infection.