scispace - formally typeset
K

Kristin J. Olsen

Researcher at University of Miami

Publications -  17
Citations -  3131

Kristin J. Olsen is an academic researcher from University of Miami. The author has contributed to research in topics: Perforin & Cytotoxic T cell. The author has an hindex of 15, co-authored 17 publications receiving 3057 citations. Previous affiliations of Kristin J. Olsen include University of Zurich.

Papers
More filters
Journal ArticleDOI

Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice

David Kägi, +8 more
- 05 May 1994 - 
TL;DR: Perforin-deficient mice have been generated by homologous recombination to determine whether the effects of CDS+ cytolytic T cells and natural killer cells are mediated by pore formation involving perform, and perforin is therefore a key effector molecule for T-cell- and natural Killer- cell-mediated cy tolysis.
Journal ArticleDOI

Structure and function of human perforin.

Mathias G. Lichtenheld, +6 more
- 29 Sep 1988 - 
TL;DR: The primary structure of human P1 is determined, its functional properties are re-examine, and the question of homologous restriction factor is addressed.
Journal ArticleDOI

Serial killing by cytotoxic T lymphocytes: T cell receptor triggers degranulation, re-filling of the lytic granules and secretion of lytic proteins via a non-granule pathway.

Sylvie Isaaz, +4 more
- 01 Apr 1995 - 
TL;DR: CD8+ cytotoxic T lymphocyte (CTL) clones begin to synthesize the lytic proteins granzyme A, granzyme B and perforin after stimulation with allogeneic target cells.
Journal Article

Perforin, Fas ligand, and tumor necrosis factor are the major cytotoxic molecules used by lymphokine-activated killer cells.

Richard K. Lee, +4 more
- 01 Sep 1996 - 
TL;DR: LAK cells are armed with at least three cytotoxic molecules: perforin, Fas ligand, and TNF, and this potent TNF cytotoxicity has not been fully appreciated previously.
Journal ArticleDOI

Cloning, analysis, and expression of murine perforin 1 cDNA, a component of cytolytic T-cell granules with homology to complement component C9

David M. Lowrey, +6 more
- 01 Jan 1989 - 
TL;DR: The nucleotide sequence coding for the cytotoxic T-lymphocyte (CTL) protein perforin 1 (P1) has been determined and the corresponding protein sequence has been derived.