Peter Seiler

TL;DR: Perforin-deficient mice have been generated by homologous recombination to determine whether the effects of CDS+ cytolytic T cells and natural killer cells are mediated by pore formation involving perform, and perforin is therefore a key effector molecule for T-cell- and natural Killer- cell-mediated cy tolysis.

TL;DR: In this paper, the tuberculosis vaccine Mycobacterium bovis bacille Calmette-Guerin (BCG) was equipped with the membrane-perforating listeriolysin (Hly) of Listeria monocytogenes.

TL;DR: It is suggested that perforin‐dependent cytotoxicity mediated by T cells is crucial for protection against noncytopathic viruses, whereas infections with cytopATHic viruses are controlled by nonlytic T cell‐dependent soluble mediators such as cytokines and neutralizing antibodies.

TL;DR: Perforin-dependent cytotoxicity is a crucial effector mechanism for β cell elimination by cytotoxic T cells in autoimmune diabetes, however, in the absence of perforin chronic inflammation of the islets can lead to diabetogenic β cell loss by less efficient secondary effector mechanisms.

TL;DR: To identify the cell populations responsible for Ag trapping in the marginal zone, mice were selectively depleted of marginal zone macrophage and marginal metallophilic macrophages, and in the absence of these cells, trapping of microspheres and Listeria monocytogenes organisms was lost, and early control of infection was impaired.