Kristina A. Ganzinger

TL;DR: In this paper, the interactions between human clusterin and the Alzheimer's disease-associated amyloid-β(1-40) peptide (Aβ( 1-40)), which is prone to aggregate into an ensemble of oligomeric intermediates implicated in both the proliferation of amylid fibrils and in neuronal toxicity, were examined.

TL;DR: The structural basis for, and the potent signaling effects of, local CD45 and kinase segregation are revealed, and TCR ligands have the potential to heighten signaling simply by holding receptors in close contacts.

TL;DR: The concentrations and numbers of aggregates necessary for the effective seeding of alpha-synuclein are determined, thus providing a quantitative framework to understand the conditions when its seeded propagation is favorable and suggesting that effective templated seeding is likely to require both the presence of template aggregates and conditions of cellular stress.

TL;DR: This study demonstrates the power of single-molecule imaging techniques for characterizing the interactions between protein aggregates and the membranes of live neuronal cells at physiologically relevant concentrations and opens the door to quantitative studies of the cellular responses to potentially pathogenic oligomers.

TL;DR: YjiE is the first described hypochlorite-specific transcription factor, YjiE, which conserved in proteobacteria and eukaryotes and regulates a large number of genes upon hypchlorite stress, thus supposedly replenishing oxidized metabolites and decreasing the hypoch chlorite-mediated amplification of intracellular reactive oxygen species.