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Andreas Kastenmüller
Researcher at Center for Integrated Protein Science Munich
Publications - 9
Citations - 675
Andreas Kastenmüller is an academic researcher from Center for Integrated Protein Science Munich. The author has contributed to research in topics: Chaperone (protein) & Heat shock protein. The author has an hindex of 9, co-authored 9 publications receiving 605 citations. Previous affiliations of Andreas Kastenmüller include Technische Universität München.
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Journal ArticleDOI
Regulated structural transitions unleash the chaperone activity of αB-crystallin
Jirka Peschek,Nathalie Braun,Julia Rohrberg,Katrin C. Back,Thomas Kriehuber,Andreas Kastenmüller,Sevil Weinkauf,Johannes Buchner +7 more
TL;DR: It is shown that phosphorylation-induced destabilization of intersubunit interactions mediated by the N-terminal domain (NTD) results in the remodeling of the oligomer ensemble with an increase in smaller, activated species, predominantly 12-mers and 6-mers.
Journal ArticleDOI
Multiple molecular architectures of the eye lens chaperone αB-crystallin elucidated by a triple hybrid approach.
Nathalie Braun,Martin Zacharias,Jirka Peschek,Andreas Kastenmüller,Juan Zou,Marianne Hanzlik,Martin Haslbeck,Juri Rappsilber,Johannes Buchner,Sevil Weinkauf +9 more
TL;DR: This work presents a pseudoatomic model of a 24-meric αB-crystallin assembly obtained by a triple hybrid approach combining data from cryoelectron microscopy, NMR spectroscopy, and structural modeling, and explains how “heterogeneity” is achieved by a small set of defined structural variations.
Journal ArticleDOI
Leucine-rich repeat kinase 2 binds to neuronal vesicles through protein interactions mediated by its C-terminal WD40 domain.
Giovanni Piccoli,Giovanni Piccoli,Franco Onofri,Maria Daniela Cirnaru,Christoph J. O. Kaiser,Pravin Kumar Ankush Jagtap,Andreas Kastenmüller,Francesca Pischedda,Antonella Marte,Felix von Zweydorf,Andreas Vogt,Andreas Vogt,Florian Giesert,Lifeng Pan,Flavia Antonucci,Christina Kiel,Mingjie Zhang,Sevil Weinkauf,Michael Sattler,Carlo Sala,Michela Matteoli,Marius Ueffing,Marius Ueffing,Christian Johannes Gloeckner,Christian Johannes Gloeckner +24 more
TL;DR: A domain-based pulldown approach combined with mass spectrometric analysis identified LRRK2 as being part of a highly specific protein network involved in synaptic vesicle trafficking, and demonstrated a critical role of the WD40 domain within L RRK2 function.
Journal ArticleDOI
Vibralactone as a tool to study the activity and structure of the ClpP1P2 complex from Listeria monocytogenes.
Evelyn Zeiler,Nathalie Braun,Thomas Böttcher,Andreas Kastenmüller,Sevil Weinkauf,Stephan A. Sieber +5 more
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Identification of a hypochlorite-specific transcription factor from Escherichia coli.
Katharina M. Gebendorfer,Adrian Drazic,Yan Le,Jasmin Gundlach,Alexander Bepperling,Andreas Kastenmüller,Kristina A. Ganzinger,Nathalie Braun,Titus M. Franzmann,Jeannette Winter +9 more
TL;DR: YjiE is the first described hypochlorite-specific transcription factor, YjiE, which conserved in proteobacteria and eukaryotes and regulates a large number of genes upon hypchlorite stress, thus supposedly replenishing oxidized metabolites and decreasing the hypoch chlorite-mediated amplification of intracellular reactive oxygen species.