K
Kristina Gervin
Researcher at University of Oslo
Publications - 47
Citations - 1229
Kristina Gervin is an academic researcher from University of Oslo. The author has contributed to research in topics: DNA methylation & Medicine. The author has an hindex of 18, co-authored 35 publications receiving 997 citations. Previous affiliations of Kristina Gervin include Oslo University Hospital.
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Journal ArticleDOI
DNA methylation and gene expression changes in monozygotic twins discordant for psoriasis: identification of epigenetically dysregulated genes.
Kristina Gervin,Magnus Dehli Vigeland,Morten Mattingsdal,Martin Hammerø,Heidi Nygård,Anne O. Olsen,Ingunn Brandt,Jennifer R. Harris,Dag E. Undlien,Robert Lyle +9 more
TL;DR: In this article, the first study based on data from MZ twins discordant for psoriasis to detect epigenetic alterations that potentially contribute to development of the disease was presented.
Journal ArticleDOI
Systematic evaluation and validation of reference and library selection methods for deconvolution of cord blood DNA methylation data
Kristina Gervin,Lucas A. Salas,Kelly M. Bakulski,Menno C. van Zelm,Menno C. van Zelm,Devin C. Koestler,John K. Wiencke,Liesbeth Duijts,Liesbeth Duijts,Henriëtte A. Moll,Karl T. Kelsey,Michael S. Kobor,Robert Lyle,Robert Lyle,Brock C. Christensen,Janine F. Felix,Janine F. Felix,Meaghan J Jones +17 more
TL;DR: This work systematically evaluates and compares four reference datasets comprising DNAm signatures profiled in purified cell populations using the Illumina 450 K and EPIC arrays and establishes a framework for combining reference datasets in other tissues.
Journal ArticleDOI
Limitations and possibilities of low cell number ChIP-seq
Gregor D. Gilfillan,Timothy P. Hughes,Ying Sheng,Hanne Sagsveen Hjorthaug,Tobias Straub,Kristina Gervin,Jennifer R. Harris,Dag E. Undlien,Robert Lyle +8 more
TL;DR: An enhanced native ChIP-seq method tailored to low cell numbers is presented that represents a 200-fold reduction in input requirements over existing protocols and extends the applicability of the technique to isolated primary cells and rare cell populations.
Journal ArticleDOI
Mutation screening of PTPN22: association of the 1858T-allele with Addison's disease.
Beate Skinningsrud,Eystein S. Husebye,Eystein S. Husebye,Kristina Gervin,Kristian Løvås,Kristian Løvås,Anne Blomhoff,Anette S. B. Wolff,E. Helen Kemp,Thore Egeland,Dag E. Undlien +10 more
TL;DR: It is concluded that the 1858T-allele is a PTPN22 genetic susceptibility factor for autoimmune AD, and other rare variants in PTPn22 do occur, and may also be involved in the pathogenesis.
Journal ArticleDOI
Genome-wide blood DNA methylation alterations at regulatory elements and heterochromatic regions in monozygotic twins discordant for obesity and liver fat
Miina Ollikainen,Khadeeja Ismail,Kristina Gervin,Anjuska Kyllönen,Antti Hakkarainen,Jesper Lundbom,Elina Järvinen,Jennifer R. Harris,Nina Lundbom,Aila Rissanen,Robert Lyle,Kirsi H. Pietiläinen,Kirsi H. Pietiläinen,Jaakko Kaprio,Jaakko Kaprio +14 more
TL;DR: The methylome in leukocytes is altered in obesity associated with metabolic disturbances, and the findings indicate several novel candidate genes and pathways in obesity and obesity-related complications.