Krystian Pluta

TL;DR: The phenothiazine core is revealed to be very potent pharmacophoric moiety which can be a rich source of new compounds having desirable biological activities.

TL;DR: The first demonstration of significant azaphenothiazine anticancer activity is demonstrated using cell lines from various cancers including leukemia, non-small cell lung cancer, colon cancer, central nervous system cancer, prostate cancer, ovarian cancer and breast cancer.

TL;DR: Phenothiazine (10H-dibenzo-1,4-thiazine, I) was obtained for the first time by Bernthsen in 1883 in the thionation of diphenylamine as mentioned in this paper.

TL;DR: This study evaluated the activities of new types of azaphenothiazines in the following immunological assays: the proliferative response of human peripheral blood mononuclear cells induced by phytohemagglutin A or anti-CD3 antibodies; lipopolysaccharide-induced cytokine production by human PBMC; the secondary, humoral immune response in mice to sheep erythrocytes (in vitro); and delayed-type hypersensitivity in mice

TL;DR: This review summarizes the methodical knowledge on azaphenothiazines, referring to their nomenclature, synthesis, structure analysis and above all significant varied biological activities, examined in vitro and in–vivo.