Journal ArticleDOI
Synthesis and properties of diaza-, triaza-, and tetraazaphenothiazines
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TLDR
Phenothiazine (10H-dibenzo-1,4-thiazine, I) was obtained for the first time by Bernthsen in 1883 in the thionation of diphenylamine as mentioned in this paper.About:
This article is published in Journal of Heterocyclic Chemistry.The article was published on 2009-05-01. It has received 42 citations till now. The article focuses on the topics: Phenothiazine & Diphenylamine.read more
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Recent progress in biological activities of synthesized phenothiazines.
TL;DR: The phenothiazine core is revealed to be very potent pharmacophoric moiety which can be a rich source of new compounds having desirable biological activities.
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Azaphenothiazines - promising phenothiazine derivatives. An insight into nomenclature, synthesis, structure elucidation and biological properties.
Krystian Pluta,Małgorzata Jeleń,Beata Morak-Młodawska,Michał Zimecki,Jolanta Artym,Maja Kocięba,Ewa Zaczyńska +6 more
TL;DR: This review summarizes the methodical knowledge on azaphenothiazines, referring to their nomenclature, synthesis, structure analysis and above all significant varied biological activities, examined in vitro and in–vivo.
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6-Substituted 9-fluoroquino[3,2-b]benzo[1,4]thiazines display strong antiproliferative and antitumor properties
Małgorzata Jeleń,Krystian Pluta,Michał Zimecki,Beata Morak-Młodawska,Jolanta Artym,Maja Kocięba +5 more
TL;DR: 6-Substituted 9-fluoroquino[3,2-b]benzo[1,4]thiazines - a new type of tetracyclic azaphenothiazines-were obtained by the introduction of appropriate substituents to the thiazine nitrogen atom and showed differential cytotoxic as well as antiproliferative actions against human peripheral blood mononuclear cells stimulated with phytohemagglutinin A.
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Synthesis and selected immunological properties of 10-substituted 1,8-diazaphenothiazines.
Beata Morak-Młodawska,Krystian Pluta,Michał Zimecki,Małgorzata Jeleń,Jolanta Artym,Maja Kocięba +5 more
TL;DR: The compounds showing the highest antiproliferative activity strongly inhibited the growth of leukemia L-1210 and colon cancer SW-948 cell lines, similarly as cisplatin, a reference drug.
Journal ArticleDOI
Synthesis, spectroscopic characterization, and anticancer activity of new 10-substituted 1,6-diazaphenothiazines.
TL;DR: New phenothiazine derivatives as 10-substituted dipyridothiazines of the 1,6-diazaphenothiazined structure were obtained in the cyclization reaction of 3-amino-3′-nitro-2,2′-dipyridinyl sulfide and 3,3″-dinitropyridine followed by various alkylation and arylation reactions.
References
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Enhanced killing of intracellular multidrug-resistant Mycobacterium tuberculosis by compounds that affect the activity of efflux pumps
TL;DR: A model is presented which describes the mechanisms by which distinct efflux pumps of the phagosome-lysosome complex are inhibited by agents that are known to inhibit K(+) flux, and identifies a variety of agents that address these characteristics and therefore have potential for managing MDR-TB.
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Antitumor Potential and Possible Targets of Phenothiazine-Related Compounds
TL;DR: Benzo[a]phenothiazines induced monocytic differentiation and apoptotic cell death in human myelogenous leukemic cell lines, but not in other cancer cell lines; these data suggest their possible applicability of "half-mustard type" phenothiazine and benzo[ a]phenothsiazines for cancer chemotherapy.
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Design and synthesis of pyrimido[4,5-b][1,4]benzothiazine derivatives, as potent 15-lipoxygenase inhibitors.
TL;DR: A group of 2-substituted pyrimido[4,5-b][1,4]benzothiazines designed, synthesized, and evaluated as potential inhibitors of 15-lipoxygenase suggest the interaction of the iron atom is essential for the activity of the inhibitors.