K
Kuang-Hueih Chen
Researcher at Queen's University
Publications - 31
Citations - 1701
Kuang-Hueih Chen is an academic researcher from Queen's University. The author has contributed to research in topics: Mitochondrial fission & mitochondrial fusion. The author has an hindex of 16, co-authored 27 publications receiving 1341 citations. Previous affiliations of Kuang-Hueih Chen include National Institutes of Health & Peking University.
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Journal ArticleDOI
Dysregulation of HSG triggers vascular proliferative disorders
Kuang-Hueih Chen,Xiaomei Guo,Dalong Ma,Yanhong Guo,Qian Li,Dongmei Yang,Peng-fei Li,Xiaoyan Qiu,Shaojun Wen,Rui-Ping Xiao,Rui-Ping Xiao,Jian Tang +11 more
TL;DR: RHSG functions as a cell proliferation suppressor, whereas dysregulation of rHSG results in proliferative disorders, whereas rHSg-induced anti-proliferation was independent of mitochondrial fusion.
Journal ArticleDOI
Mitofusin-2 Is a Major Determinant of Oxidative Stress-mediated Heart Muscle Cell Apoptosis
Tao Shen,Ming Zheng,Chun-Mei Cao,Chunlei Chen,Jian Tang,Wanrui Zhang,Heping Cheng,Kuang-Hueih Chen,Rui-Ping Xiao,Rui-Ping Xiao +9 more
TL;DR: It is indicated that increased cardiac Mfn-2 expression is both necessary and sufficient for oxidative stress-induced heart muscle cell apoptosis, suggesting that M fn-2 deregulation may be a crucial pathogenic element and a potential therapeutic target for heart failure.
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Mitofusin 2 Triggers Vascular Smooth Muscle Cell Apoptosis via Mitochondrial Death Pathway
TL;DR: It is demonstrated that mitofusin 2 is a primary determinant of VSMC apoptosis and silencing protects VSMCs against H2O2 or Mfn-2 overexpression–induced apoptosis, indicating that upregulation of M fn-2 is necessary and sufficient for oxidative stress–mediated VS MC apoptosis.
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MicroRNA-138 and MicroRNA-25 Down-regulate Mitochondrial Calcium Uniporter, Causing the Pulmonary Arterial Hypertension Cancer Phenotype
Zhigang Hong,Kuang-Hueih Chen,Asish Dasgupta,François Potus,Kimberly J. Dunham-Snary,Sébastien Bonnet,Lian Tian,Jennifer Fu,Sandra Breuils-Bonnet,Steeve Provencher,Danchen Wu,Jeffrey Mewburn,Mark L. Ormiston,Stephen L. Archer +13 more
TL;DR: In this paper, the pore-forming subunit, MCU, was manipulated through small interfering RNA knockdown or MCU plasmid-mediated up-regulation, as well as through modulation of the upstream microRNAs (miRs) miR-138 and miR25.
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Role of mitofusin 2 (Mfn2) in controlling cellular proliferation
TL;DR: Mfn2 exerts its antiproliferative effect by acting as an effector molecule of Ras, resulting in the inhibition of the Ras‐Raf‐ERK signaling pathway and new insights regarding the role of Mfn2 in controlling cellular proliferation are provided.