P
Paritosh Ghosh
Researcher at National Institutes of Health
Publications - 52
Citations - 3328
Paritosh Ghosh is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Signal transduction & Enhancer. The author has an hindex of 29, co-authored 49 publications receiving 3138 citations. Previous affiliations of Paritosh Ghosh include Baylor College of Medicine & University of Miami.
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Journal ArticleDOI
Interaction of NF-κB and NFAT with the Interferon-γ Promoter
Antonio Sica,Linda Dorman,Vincenzo Viggiano,Marco Cippitelli,Paritosh Ghosh,Nancy A. Rice,Howard A. Young +6 more
TL;DR: Results demonstrate that the coordinate activities of NFAT and NF-κB proteins are involved in the molecular mechanisms controlling IFN-γ gene transcription.
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Phosphorylation of RelA/p65 on Serine 536 Defines an IκBα-independent NF-κB Pathway
TL;DR: It is demonstrated that the regulation of nuclear translocation of p65 phosphorylated on serine 536 is not associated with or regulated by IκBα, that it has a distinct set of target genes, and that it may represent a noncanonical NF-κB pathway that is independent of IkkBα regulation.
Journal Article
Differentiation of the T helper phenotypes by analysis of the methylation state of the IFN-gamma gene.
Howard A. Young,Paritosh Ghosh,Jianping Ye,James A. Lederer,Andrew H. Lichtman,J R Gerard,L Penix,Christopher B. Wilson,A J Melvin,M E McGurn +9 more
TL;DR: It is demonstrated that the methylation status of a CpG dinucleotide contained within a TATA proximal regulatory element of the IFN-gamma promoter correlates with the transcription of the gene.
Journal Article
Inhibitors of both nuclear factor-κB and activator protein-1 activation block the neoplastic transformation response
TL;DR: Results suggest that both AP-1 and NF-kappaB activation may be required for transformation whether induced by TPA or by TNF, and the differential sensitivity of TPA and TNF-alpha-induced transformation to inhibition by a retinoid might be explained by differences in the composition of the DNA-bound AP- 1 complexes.
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The interleukin 2 CD28-responsive complex contains at least three members of the NF kappa B family: c-Rel, p50, and p65.
TL;DR: It is shown that in human peripheral blood T cells, CD28-mediated signal transduction involves the rel family proteins--c-Rel, p50, and p65, and this augmentation can occur in the presence of the immunosuppressant cyclosporin A.