K
Kuljit Singh
Researcher at Rajendra Memorial Research Institute of Medical Sciences
Publications - 10
Citations - 178
Kuljit Singh is an academic researcher from Rajendra Memorial Research Institute of Medical Sciences. The author has contributed to research in topics: Leishmania donovani & Trypanothione. The author has an hindex of 8, co-authored 10 publications receiving 131 citations.
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Journal ArticleDOI
Current Therapeutics, Their Problems and Thiol Metabolism as Potential Drug Targets in Leishmaniasis.
TL;DR: The aspects of chemotherapy of leishmaniasis by synthetic and natural drugs, their mechanism of action, pharmacokinetics and involvement in the development of drug resistance are reviewed.
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Deciphering the interplay between cysteine synthase and thiol cascade proteins in modulating Amphotericin B resistance and survival of Leishmania donovani under oxidative stress.
Kuljit Singh,Vahab Ali,Vahab Ali,Krishn Pratap Singh,Parool Gupta,Shashi S. Suman,Ayan Kumar Ghosh,Sanjiva Bimal,Krishna Pandey,Pradeep Das +9 more
TL;DR: It is reported that over-expression of LdCS in Amphotericin B (Amp B) sensitive strain (S1-OE) modulates resistance towards oxidative stress and drug pressure, and reveals a novel crosstalk between Ld CS and thiol metabolic pathway proteins and demonstrates the crucial role in drug resistance and redox homeostasis of Leishmania.
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Up-regulation of cytosolic tryparedoxin in Amp B resistant isolates of Leishmania donovani and its interaction with cytosolic tryparedoxin peroxidase.
Shashi S. Suman,Asif Equbal,Amir Zaidi,M.Y. Ansari,Krishn Pratap Singh,Kuljit Singh,Bidyut Purkait,Ganesh Chandra Sahoo,Sanjiva Bimal,Pradeep Das,Ali +10 more
TL;DR: It is demonstrated at the translational level that Ld-cTXN protein is upregulated in Amp B resistant isolates accompanied by enhanced peroxidase activity, as compared to sensitive strains.
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Elevated Serum ADA Activity as a Marker for Diagnosis and Prognosis of Visceral Leishmaniasis and Post Kala-Azar Dermal Leishmaniasis in Indian Patients.
Vijayamahantesh,Ajay Amit,Manas Ranjan Dikhit,Raj Kishor Pandey,Raj Kishor Pandey,Kuljit Singh,Ritesh Mishra,Vidya Nand Rabi Das,Pradeep Das,Sanjiva Bimal +9 more
TL;DR: The results suggest the possibility of ADA as a marker of clinical pathogenesis and can be used as a surrogate marker in the diagnosis and prognosis of VL and PKDL.
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Proteomic approaches unravel the intricacy of secreted proteins of Leishmania: An updated review.
TL;DR: Various secretion mechanisms used by Leishmania parasites to export the proteins into the extracellular space are summarized; followed by the role of proteomics in exoproteome analysis along with special emphasis on various applications to study the exoproteinome, which might provide potential targets for drug design or novel antigens for vaccine development.