K
Kullervo Hynynen
Researcher at Sunnybrook Research Institute
Publications - 242
Citations - 10771
Kullervo Hynynen is an academic researcher from Sunnybrook Research Institute. The author has contributed to research in topics: Ultrasound & Microbubbles. The author has an hindex of 52, co-authored 242 publications receiving 8148 citations. Previous affiliations of Kullervo Hynynen include Sunnybrook Health Sciences Centre & Brigham and Women's Hospital.
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Journal ArticleDOI
Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
Nir Lipsman,Nir Lipsman,Ying Meng,Allison Bethune,Allison Bethune,Yuexi Huang,Benjamin Lam,Mario Masellis,Nathan Herrmann,Chinthaka Heyn,Isabelle Aubert,Isabelle Aubert,Alexandre Boutet,Gwenn S. Smith,Kullervo Hynynen,Kullervo Hynynen,Sandra E. Black +16 more
TL;DR: The results of this safety and feasibility study support the continued investigation of focused ultrasound as a potential novel treatment and delivery strategy for patients with Alzheimer’s disease and show that the procedure is safe.
Targeted disruption of the blood-brain barrier with focused ultrasound
TL;DR: A significant increase in the emission signal due to Optison at the second and third harmonics of the ultrasound driving frequency was found to correlate with BBBD and might be useful as an online method to indicate when the disruption occurs.
Journal ArticleDOI
Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study
Todd G. Mainprize,Nir Lipsman,Nir Lipsman,Yuexi Huang,Ying Meng,Ying Meng,Allison Bethune,Sarah Ironside,Chinthaka Heyn,Ryan Alkins,Maureen Trudeau,Arjun Sahgal,Arjun Sahgal,James Perry,James Perry,Kullervo Hynynen,Kullervo Hynynen +16 more
TL;DR: In this article, the MRgFUS with intravenously injected microbubbles can temporarily and repeatedly disrupt the blood-brain barrier (BBB) in a targeted fashion, without open surgery.
Journal ArticleDOI
Antibodies Targeted to the Brain with Image-Guided Focused Ultrasound Reduces Amyloid-β Plaque Load in the TgCRND8 Mouse Model of Alzheimer's Disease
Jessica F. Jordão,Carlos A. Ayala-Grosso,Carlos A. Ayala-Grosso,Kelly Markham,Yuexi Huang,Rajiv Chopra,Rajiv Chopra,JoAnne McLaurin,Kullervo Hynynen,Kullervo Hynynen,Isabelle Aubert,Isabelle Aubert +11 more
TL;DR: This is the first report to demonstrate that MRIgFUS delivery of anti-Aβ antibodies provides the combined advantages of using a low dose of antibody and rapidly reducing plaque pathology.
Journal ArticleDOI
Blood-brain barrier: real-time feedback-controlled focused ultrasound disruption by using an acoustic emissions-based controller.
TL;DR: This study demonstrates that acoustic emissions can be used to actively control focused ultrasound exposures for the safe induction of BBB disruption and reveals gross tissue damage at higher scaling levels.