C
Chinthaka Heyn
Researcher at Sunnybrook Health Sciences Centre
Publications - 38
Citations - 1584
Chinthaka Heyn is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 11, co-authored 23 publications receiving 898 citations. Previous affiliations of Chinthaka Heyn include University of Toronto & Sunnybrook Research Institute.
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Journal ArticleDOI
Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
Nir Lipsman,Nir Lipsman,Ying Meng,Allison Bethune,Allison Bethune,Yuexi Huang,Benjamin Lam,Mario Masellis,Nathan Herrmann,Chinthaka Heyn,Isabelle Aubert,Isabelle Aubert,Alexandre Boutet,Gwenn S. Smith,Kullervo Hynynen,Kullervo Hynynen,Sandra E. Black +16 more
TL;DR: The results of this safety and feasibility study support the continued investigation of focused ultrasound as a potential novel treatment and delivery strategy for patients with Alzheimer’s disease and show that the procedure is safe.
Journal ArticleDOI
Blood-Brain Barrier Opening in Primary Brain Tumors with Non-invasive MR-Guided Focused Ultrasound: A Clinical Safety and Feasibility Study
Todd G. Mainprize,Nir Lipsman,Nir Lipsman,Yuexi Huang,Ying Meng,Ying Meng,Allison Bethune,Sarah Ironside,Chinthaka Heyn,Ryan Alkins,Maureen Trudeau,Arjun Sahgal,Arjun Sahgal,James Perry,James Perry,Kullervo Hynynen,Kullervo Hynynen +16 more
TL;DR: In this article, the MRgFUS with intravenously injected microbubbles can temporarily and repeatedly disrupt the blood-brain barrier (BBB) in a targeted fashion, without open surgery.
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First-in-human trial of blood-brain barrier opening in amyotrophic lateral sclerosis using MR-guided focused ultrasound
Agessandro Abrahao,Agessandro Abrahao,Ying Meng,Ying Meng,Maheleth Llinas,Maheleth Llinas,Yuexi Huang,Clement Hamani,Clement Hamani,Todd G. Mainprize,Isabelle Aubert,Isabelle Aubert,Chinthaka Heyn,Sandra E. Black,Kullervo Hynynen,Nir Lipsman,Nir Lipsman,Lorne Zinman +17 more
TL;DR: It is demonstrated that non-invasive BBB permeabilization over the motor cortex using MRgFUS is safe, feasible, and reversible in ALS subjects, and suggested that the procedure could in the future be used to increase drug delivery in ALS patients.
Journal ArticleDOI
Glymphatics Visualization after Focused Ultrasound-Induced Blood-Brain Barrier Opening in Humans.
Ying Meng,Ying Meng,Agessandro Abrahao,Agessandro Abrahao,Chinthaka Heyn,Chinthaka Heyn,Allison Bethune,Allison Bethune,Yuexi Huang,Christopher B Pople,Isabelle Aubert,Isabelle Aubert,Clement Hamani,Clement Hamani,Lorne Zinman,Lorne Zinman,Kullervo Hynynen,Kullervo Hynynen,Sandra E. Black,Sandra E. Black,Nir Lipsman,Nir Lipsman +21 more
TL;DR: This work describes patterns of contrast distribution in the perivascular space, subarachnoid space, and space surrounding large veins draining toward the dural sinuses on fluid‐attenuated inversion recovery in subjects with Alzheimer disease and amyotrophic lateral sclerosis, first evidence suggesting glymphatic efflux persists in humans.
Journal ArticleDOI
Differentiating radiation necrosis from tumor progression in brain metastases treated with stereotactic radiotherapy: utility of intravoxel incoherent motion perfusion MRI and correlation with histopathology.
Jay Detsky,Julia Keith,John Conklin,Sean P. Symons,Sten Myrehaug,Arjun Sahgal,Chinthaka Heyn,Hany Soliman +7 more
TL;DR: Intravoxel incoherent motion shows promise in differentiating recurrent tumor from radiation necrosis for brain metastases treated with radiosurgery, but needs to be validated in a larger cohort.