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Alexandre Boutet
Researcher at University of Toronto
Publications - 104
Citations - 2486
Alexandre Boutet is an academic researcher from University of Toronto. The author has contributed to research in topics: Deep brain stimulation & Medicine. The author has an hindex of 16, co-authored 74 publications receiving 1098 citations. Previous affiliations of Alexandre Boutet include Montreal Neurological Institute and Hospital & University Health Network.
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Journal ArticleDOI
Blood–brain barrier opening in Alzheimer’s disease using MR-guided focused ultrasound
Nir Lipsman,Nir Lipsman,Ying Meng,Allison Bethune,Allison Bethune,Yuexi Huang,Benjamin Lam,Mario Masellis,Nathan Herrmann,Chinthaka Heyn,Isabelle Aubert,Isabelle Aubert,Alexandre Boutet,Gwenn S. Smith,Kullervo Hynynen,Kullervo Hynynen,Sandra E. Black +16 more
TL;DR: The results of this safety and feasibility study support the continued investigation of focused ultrasound as a potential novel treatment and delivery strategy for patients with Alzheimer’s disease and show that the procedure is safe.
Journal ArticleDOI
Technology of deep brain stimulation: current status and future directions.
Joachim K. Krauss,Nir Lipsman,Tipu Z. Aziz,Alexandre Boutet,Peter Brown,Jin Woo Chang,Benjamin Davidson,Warren M. Grill,Marwan Hariz,Andreas Horn,Michael Schulder,Antonios Mammis,Peter A. Tass,Jens Volkmann,Andres M. Lozano +14 more
TL;DR: The evolution and current status of DBS technology is discussed, future advances are anticipated, and the next major technological advances and hurdles in the field are predicted.
Journal ArticleDOI
A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
Ningfei Li,Juan Carlos Baldermann,Astrid Kibleur,Svenja Treu,Harith Akram,Gavin J B Elias,Alexandre Boutet,Alexandre Boutet,Andres M. Lozano,Bassam Al-Fatly,Bryan A. Strange,Juan A. Barcia,Ludvic Zrinzo,Eileen M. Joyce,Stephan Chabardes,Veerle Visser-Vandewalle,Mircea Polosan,Mircea Polosan,Jens Kuhn,Andrea A. Kühn,Andreas Horn +20 more
TL;DR: Structural connectivity of deep brain stimulation electrodes in 50 patients suffering from obsessive-compulsive disorder operated at four centers showed connectivity to a specific tract within the anterior limb of the internal capsule was associated with optimal treatment response across cohorts, surgeons and centers.
Journal ArticleDOI
Focused ultrasound thalamotomy location determines clinical benefits in patients with essential tremor.
Alexandre Boutet,Manish Ranjan,Jidan Zhong,Jürgen Germann,David S. Xu,Michael L. Schwartz,Nir Lipsman,Kullervo Hynynen,Kullervo Hynynen,Gabriel A. Devenyi,M. Mallar Chakravarty,Eugen Hlasny,Maheleth Llinas,Christopher S Lozano,Gavin J B Elias,Jason R. Chan,Ailish Coblentz,Alfonso Fasano,Walter Kucharczyk,Walter Kucharczyk,Mojgan Hodaie,Andres M. Lozano +21 more
TL;DR: Tremor improvement and acute adverse effects of MRgFUS for essential tremor are highly dependent on the location and size of lesions.
Journal ArticleDOI
Predicting optimal deep brain stimulation parameters for Parkinson’s disease using functional MRI and machine learning
Alexandre Boutet,Alexandre Boutet,Radhika Madhavan,Gavin J B Elias,Suresh Emmanuel Joel,Robert Gramer,Manish Ranjan,Vijayashankar Paramanandam,David S. Xu,Jürgen Germann,Aaron Loh,Suneil K. Kalia,Mojgan Hodaie,Bryan K. Li,Sreeram Prasad,Ailish Coblentz,Renato P. Munhoz,Jeffrey Michael Ashe,Walter Kucharczyk,Alfonso Fasano,Alfonso Fasano,Andres M. Lozano,Andres M. Lozano +22 more
TL;DR: In this paper, the authors examined whether functional magnetic resonance imaging (fMRI) can be used to predict optimal stimulation settings for individual patients with Parkinson's disease (PD) using a machine learning model.