K
Kun Peng
Publications - 7
Citations - 181
Kun Peng is an academic researcher. The author has contributed to research in topics: Aryl & Glycosidic bond. The author has an hindex of 6, co-authored 7 publications receiving 170 citations.
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Journal ArticleDOI
Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes.
Ge Xu,Binhua Lv,Jacques Y. Roberge,Baihua Xu,Jiyan Du,Jiajia Dong,Yuanwei Chen,Kun Peng,Lili Zhang,Xinxing Tang,Yan Feng,Min Xu,Wei Fu,Wenbin Zhang,Liangcheng Zhu,Zhongping Deng,Zelin Sheng,Ajith Welihinda,Xun Sun +18 more
TL;DR: S GLT2 inhibitors deuterated at sites susceptible to oxidative metabolism were found to have a slightly longer tmax and half-life, dose-dependent increase in urinary glucose excretion in rats, and slightly superior effects on UGE in dogs while retaining similar in vitro inhibitory activities against hSGLT2.
Journal ArticleDOI
Exploration of O-spiroketal C-arylglucosides as novel and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors.
Binhua Lv,Baihua Xu,Yan Feng,Kun Peng,Ge Xu,Jiyan Du,Lili Zhang,Wenbin Zhang,Ting Zhang,Liangcheng Zhu,Haifeng Ding,Zelin Sheng,Ajith Welihinda,Brian Seed,Yuanwei Chen +14 more
TL;DR: The core spiro[isobenzofuran-1,2'-pyran] structure proved to be an effective scaffold for diversification and a number of compounds with single digit nanomolar potency and high selectivity have been synthesized.
Journal ArticleDOI
C-Aryl glucosides substituted at the 4′-position as potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes
Baihua Xu,Yan Feng,Cheng Huawei,Yanli Song,Binhua Lv,Wu Yuelin,Congna Wang,Shengbin Li,Min Xu,Jiyan Du,Kun Peng,Jiajia Dong,Wenbin Zhang,Ting Zhang,Liangcheng Zhu,Haifeng Ding,Zelin Sheng,Ajith Welihinda,Jacques Y. Roberge,Brian Seed,Yuanwei Chen +20 more
TL;DR: Introduction of alkyl or alkoxy substituents at the 4'-position of the distal aryl ring was found to improve SGLT2 potency, whereas introduction of a hydrophilic group at this position was deleterious.
Journal ArticleDOI
ortho-Substituted C-aryl glucosides as highly potent and selective renal sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors
Baihua Xu,Yan Feng,Binhua Lv,Ge Xu,Lili Zhang,Jiyan Du,Kun Peng,Min Xu,Jiajia Dong,Wenbin Zhang,Ting Zhang,Liangcheng Zhu,Haifeng Ding,Zelin Sheng,Ajith Welihinda,Brian Seed,Yuanwei Chen +16 more
TL;DR: Introduction of an appropriate ortho substituent at the proximal phenyl ring adjacent to the glycosidic bond was found to improve SGLT2 inhibitory activity and dramatically increase selectivity for hS GLT2 over hSGLT1.
Patent
Deuterated benzylbenzene derivatives and methods of use
Brian Seed,Binhua Lv,Jacques Y. Roberge,Yuanwei Chen,Kun Peng,Jiajia Dong,Baihua Xu,Jiyan Du,Lili Zhang,Xinxing Tang,Ge Xu,Yan Feng,Min Xu +12 more
TL;DR: In this article, compounds having an inhibitory effect on sodium-dependent glucose cotransporter SGLT are provided. But they do not provide any methods of using these compounds, independently or in combination with other therapeutic agents, for treating diseases and conditions that are affected by sGLT inhibition.