Showing papers by "Kunikazu Tanji published in 2017"

TL;DR: The results further reinforce the association of PLA2G6 with the pathogenesis of idiopathic PD, in addition to PARK14, and use immunohistochemistry and Western blotting to investigate its involvement in Lewy body disease, multiple system atrophy and Alzheimer's disease.

TL;DR: PDHA1 is reported as a new component of brainstem-type Lewy bodies in idiopathic PD, DLB and PARK14, the level of PDHA1 protein being significantly decreased in the putamen and substantia nigra of patients with idiopathy PD, suggesting that alteration of glucose metabolism through dysfunction of the PDH complex might occur in the pathogenesis of Lewy body disease and PARK 14.

TL;DR: The results suggest that IFI 35 may negatively regulate the TLR3-IFN-β-P-STAT1-RIG-I-CXCL10/CCL5 axis in U373MG cells, and IFI35 may play a role at least partially in the regulation of innate immune reactions in astrocytes.

TL;DR: The results suggest that REB improves the cell viability by inducing genes that regulate Aβ levels and also genes that are cytoprotective in cells challenged with Aβ43.