K
Kurt A. Fegely
Researcher at United States Military Academy
Publications - 7
Citations - 218
Kurt A. Fegely is an academic researcher from United States Military Academy. The author has contributed to research in topics: Dosage form & Crystallization. The author has an hindex of 5, co-authored 7 publications receiving 204 citations.
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Journal ArticleDOI
Physicochemical characterization and mechanisms of release of theophylline from melt-extruded dosage forms based on a methacrylic acid copolymer
Christopher R. Young,Caroline Dietzsch,Matteo Cerea,Thomas P. Farrell,Kurt A. Fegely,Ali R. Rajabi-Siahboomi,James W. McGinity +6 more
TL;DR: Hot-melt extrusion was an effective process for the preparation of controlled release matrix systems based on Acryl-EZE and the influence of gelling agents on the mechanisms and kinetics of drug release from thermally processed matrices was determined.
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Crystal growth formation in melt extrudates.
TL;DR: In vitro dissolution testing showed no effect of surface crystallization of guaifenesin on drug release rates of extruded matrix tablets and the influence of hydrophilic polymeric additives including PVP K25, polycarbophil, PEG 3,350, poloxamer 188 or poly(ethylene oxide) as crystal growth inhibitors was investigated at a level of 10% based on the drug content.
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Delayed release film coating applications on oral solid dosage forms of proton pump inhibitors: case studies
TL;DR: Evaluating different formulation strategies for three PPI drugs, that is, rabeprazole sodium, lansoprazole, and esomeprazole magnesium, using delayed release film coating applications showed that Acryl-EZE enteric coating systems provide excellent performance in both media.
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Investigation of the Effects of Hydroalcoholic Solutions on Textural and Rheological Properties of Various Controlled Release Grades of Hypromellose
TL;DR: A fundamental investigation on the effect of hydroalcoholic solutions (0–40% v/v ethanol) on textural and rheological properties of different viscosity grades of neat HPMC, as the functional ingredient within a hydrophilic matrix.
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The influence of heterogeneous nucleation on the surface crystallization of guaifenesin from melt extrudates containing Eudragit® L10055 or Acryl-EZE®
TL;DR: The effects of humidity and talc on the crystallization of guaifenesin from melt-extruded dosage forms supersaturated with amorphous drug were ascribed to heterogeneous nucleation.