Showing papers in "International Journal of Pharmaceutics in 2005"

TL;DR: This article intends to discuss protein aggregation and its related mechanisms, methods characterizingprotein aggregation, factors affecting protein aggregation, and possible venues in aggregation prevention/inhibition in various stages of protein drug development.

TL;DR: It is established that particle diameters of 0.5 microm and below were optimal for DC uptake; however uptake of larger particles could be greatly enhanced by rendering the particle surface positive, remains to be established.

TL;DR: The most common stoichiometric determination during formulation studies is 1:1, i.e. one drug molecule forms a complex with one cyclodextrin molecule, and the apparent stability constant (K1:1) of the 1:2 drug/cyclodextrins complexes calculated by the phase-solubility method is found.

TL;DR: There are major differences in the calculated EC(50)-values for the cytotoxic effect of choroquine and for sodium azide depending on the assay used and it is important to choose a suitable cytotoxicity assaydepending on the supposed cell death mechanism.

TL;DR: It was showed that chitosan can complex TPP to form stable cationic nanoparticles for subsequent ammonium glycyrrhizinate loading and the introduction of PEG can decrease significantly the positive charge of particle surface.

TL;DR: The results show that sonication time, PLGA and drug amounts, PVA concentration, ratio between aqueous and organic phases, and the method of solvent evaporation have a significant influence on size distribution of the nanoparticles.

TL;DR: It has been shown that initial crystalline state is maintained following particle size reduction and that the dissolution characteristics of nifedipine nanoparticles were significantly increased in regards to the commercial product.

TL;DR: Multilamellar acetazolamide niosomes formulated with Span 60 and cholesterol in a 7:4 molar ratio were found to be the most effective and showed prolonged decrease in IOP.

TL;DR: It is concluded that chitosan-alginate multilayer beads, cross-linked with polyphosphate offer an opportunity for controlled gastrointestinal passage of compounds with low molecular weight like ampicillin.

TL;DR: The use of nanotechnologies (liposomes, nanoparticles) is especially discussed in the ultimate part of the review evidencing their potentiality as non-invasive technique in the brain delivery of drugs with the possibility to target specific brain tissue thanks to ligand linked to carrier surface.

TL;DR: In this article, the authors evaluated and compared the biodistribution profile of tamoxifen when administered intravenously (i.v.) as a simple solution or when encapsulated in polymeric nanoparticulate formulations, with or without surface-stabilizing agents.

TL;DR: Clinical studies showed that ethosomal systems were much more efficient at delivering the fluorescent substance into the skin in terms of quantity and depth, than either liposomes or hydroalcoholic solutions.

TL;DR: Methods of rapidly and accurately assessing the chemical stability of pharmaceutical dosage forms are reviewed with respect to the major degradation mechanisms generally observed in pharmaceutical development.

TL;DR: In vitro results were confirmed by brain perfusion studies on selected compounds and MDR-MDCK monolayers can be used to classify compounds into CNS-positive or CNS-negative based on the permeability coefficients (Papp, A-B).

TL;DR: The microencapsulation vesicle (MCV) method is a liposome preparation technique that reproducibly produces liposomes with homogeneous particle sizes with a high encapsulation efficiency and the logP(octanol/water) was considered to be a better indicator of the encapsulations efficiency of a drug in the MCV method.

TL;DR: The results of this study show that the p-HEMA gels loaded with a microemulsion that is stabilized with a silica shell are transparent and that these gels release drugs for a period of over 8 days.

TL;DR: The results obtained indicated that galactose coating of PPI systems increases the drug entrapment efficiency by 5-15 times depending upon generations, which can make the P PI systems more effective and suitable for targeted delivery of Primaquine phosphate to liver.

TL;DR: The effect of DL-lactide/glycolide molar ratio on drug release seemed to be dependent on the drug release mechanism, and the synthesized copolymers showed a higher gelation temperature and longer period of drug release.

TL;DR: Calcium phosphate nanoparticles were found to be dissolved even in low acidic buffer (pH 5.0) releasing the pDNA, which suggested that DNA release from these particles in the endosomal compartment was possible.

TL;DR: Polysialylation of a range of peptide and protein therapeutics has led to markedly reduced proteolysis, retention of their activity in vivo, prolongation of their half-life in the circulation and reduction in immunogenicity and antigenicity.

TL;DR: It is demonstrated that gamma-oryzanol is an organic radical scavenger able to prevent AMVN-triggered lipoperoxidation and may have a potential application for the stabilization of lipidic raw materials.

TL;DR: The results support the possibility of using Poloxamer gel as a sustained release injectable formulation, which prolongs the residence time of the lidocaine at the injection site, sustains drug release and increases therapeutic efficacy.

TL;DR: The physical state of felodipine changed from crystalline to amorphous during the CSE and SAS processes, confirmed by DSC/XRD data and solubility increased with decreasing drug/polymer ratio or increasing HCO-60 content.

TL;DR: The effectiveness of peroral F5.3 np and F6.1 np in lowering the serum glucose level of streptozotocin-induced diabetic rats was ascribed to the local effect of insulin in intestine and strong interaction between rat intestinal epithelium and chitosan nanoparticles 3h post-oral administration.

TL;DR: Experimental results confirm that dissolution rates do not only depend on the surface area and particle size of the processed powder, but are greatly affected by other physico-chemical characteristics such as crystal morphology and wettability that may reduce the benefit of micronization.

TL;DR: No relevant changes in the composition of the adsorption patterns of SLN, surface-modified with poloxamine 908 and poloxamer 407, respectively, were detected, in contrast to the chemically similarsurface-modified polymeric particles but well in agreement with the surface- modified O/W-emulsions.

TL;DR: In vitro release studies showed that the presence of the alginate layer around the particles was able to prevent a burst release of loaded ovalbumin and to improve the stability of the nanoparticles in simulated intestinal fluid at 37 degrees C.

TL;DR: Powder X-ray diffraction analysis showed that IMC in solid dispersion particles is in amorphous state irrespective of the type of silica formulated, and dissolution property of IMC was remarkably improved by formulating the silica particles to the solid Dispersion particles.

TL;DR: In vivo study revealed that topically given TT containing transfersomes, after secondary immunization, could elicit immune response (anti-TT-IgG) that was equivalent to one that produced following intramuscularly alum-adsorbed TT-based immunization.

TL;DR: In the present study, a new operating structure was developed that mimics the situation in the patient's mouth and provides a gradual elimination of the detached particles during the disintegration process of rapidly disintegrating tablets.