Kurt G. Schilling

TL;DR: The 3D Validation of Tractography with Experimental MRI (3D‐VoTEM) challenge results independently confirm findings from decades of tractography validation studies, demonstrate inherent limitations in reconstructing white matter pathways using diffusion MRI data alone, and highlight the need for alternative or combinatorial strategies to accurately map the fiber pathways of the brain.

TL;DR: 3D histological validation of diffusion MRI measures of fiber orientation provides quantitative measures of the reliability and limitations of dMRI reconstruction methods and can be used to identify relative advantages of competing approaches as well as potential strategies for improving accuracy.

TL;DR: The lessons from a decade of challenges in tractography are summarized, and perspective on the past, present, and future "challenges" that the field of diffusion tractography faces are given.

TL;DR: It is demonstrated that there is a bias for fiber tracking algorithms to terminate preferentially on gyral crowns, rather than the banks of sulci, which could significantly affect connectivity results using the current generation of tracking algorithms.

TL;DR: This technique serves as a gold standard for dMRI validation studies - providing the ability to determine the extent to which the dMRI signal is consistent with the histological FOD, and to establish how well different dMRI models can predict the ground truth FOD.