Kurt Püntener

TL;DR: Design, synthesis, and SAR of novel alpha-alkoxy-beta-arylpropionic acids as potent and balanced PPARalphagamma coagonists as well as its high efficacy in animal models of T2D and dyslipidemia are presented.

TL;DR: The first synthesis of (R)- and (S)-4-hydroxyisophorone by catalytic transfer hydrogenation of ketoisophore is reported in this paper.

TL;DR: The first enantio- and diastereoselective approach to alpha-alkoxy-substituted syn-beta-hydroxyesters through highly efficient catalytic asymmetric transfer hydrogenation via dynamic kinetic resolution reactions from the corresponding racemic beta-ketoesters is described.

TL;DR: In this paper, a new synthesis of (S)-3-amino-4-methoxy-butan-1-ol was reported based on the preparation of the primary, nonprotected enamine of the commercially available β-keto ester methyl 4methiox-3-oxo-butanoate and asymmetric catalytic enamine hydrogenation using a Ru-MeOBIPHEP catalyst.

TL;DR: An X‐ray‐guided design approach led to the identification of a novel, balanced class of α‐ethoxy‐phenylpropionic acid‐derived dual PPARα/γ agonists, which possess favorable physicochemical and pharmacokinetic profiles and show a high efficacy in T2D and dyslipidemia animal models.