Kurt Tobler

TL;DR: While the mutant virus replicated locally, induced a rise in neutralizing antibody titers, and stimulated the interferon system, no evidence for ocular illness or reactivation of the underlying wtFeHV-1-infection was detected, however, cyclophosphamide-dexamethasone (C-D) treatment, applied 16 months after the superinfection, was able to reactivate wt FeHv-1.

TL;DR: This study identified a conserved amino acid in the VP2 protein, L124, necessary for its interaction with NSP5 and the formation of both VLSs and viroplasms, and characterized the domains required for NSP 5-VP2 interaction and VLS formation.

TL;DR: The ability to easily manipulate the viral genomes on a molecular level in future experiments will lead to a better understanding of the difference in pathogenesis induced by these two closely related bovine herpesviruses.

TL;DR: It is observed that AAV2 rep gene expression is cell cycle dependent and gives rise to distinct time-controlled windows for HSV-1 replication, which may limit competition for cellular and viral helper factors and, hence, creates a biological niche for either virus to replicate.

TL;DR: It is suggested that FdPV2 is highly prevalent, even among healthy cats, however, cats that carry it on their skin mount in most instances no antibody response, and it might be hypothesized that it is only rarely productively replicating or its replication is only seldom exposed to the immune system.