K
Kurt Werner Schmid
Researcher at University of Duisburg-Essen
Publications - 534
Citations - 17090
Kurt Werner Schmid is an academic researcher from University of Duisburg-Essen. The author has contributed to research in topics: Thyroid & Thyroid carcinoma. The author has an hindex of 65, co-authored 518 publications receiving 15647 citations. Previous affiliations of Kurt Werner Schmid include University of Münster & Charité.
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Journal ArticleDOI
Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis
Volker Teichgräber,Martina Ulrich,Nicole Endlich,Joachim Riethmüller,Barbara Wilker,Cheyla Conceição De Oliveira-Munding,Anna M. van Heeckeren,Mark L. Barr,Gabriele von Kürthy,Kurt Werner Schmid,Michael Weller,Burkhard Tümmler,Florian Lang,Heike Grassmé,Gerd Döring,Erich Gulbins +15 more
TL;DR: Inhibition of Asm as a new treatment strategy for cystic fibrosis is suggested because it shows that ceramide age-dependently accumulates in the respiratory tract of uninfected Cftr-deficient mice and prevents all pathological findings, including susceptibility to infection.
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Liver cell death and anemia in Wilson disease involve acid sphingomyelinase and ceramide.
Philipp A. Lang,Marcus Schenck,Jan P. Nicolay,Jan U. Becker,Daniela S. Kempe,Adrian Lupescu,Saisudha Koka,Kerstin Eisele,Barbara A. Klarl,Herbert Rübben,Kurt Werner Schmid,Klaus Mann,Sibylle Hildenbrand,Harald Hefter,Stephan M. Huber,Thomas Wieder,Andreas Erhardt,Dieter Häussinger,Erich Gulbins,Florian Lang +19 more
TL;DR: It is shown that Cu2+ triggers hepatocyte apoptosis through activation of acid sphingomyelinase (Asm) and release of ceramide, which suggests a previously unidentified mechanism for liver cirrhosis and anemia in Wilson disease.
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Surgical cure for early rectal carcinomas (T1). Transanal endoscopic microsurgery vs. anterior resection.
TL;DR: Lower morbidity, similar local recurrence, and survival rates favor the TEM technique, and comparable results in survival rate to the gold standard (AR) are objective arguments for choosing the adequate surgical procedure.
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Posterior retroperitoneoscopic adrenalectomy--results of 560 procedures in 520 patients.
Martin K. Walz,Piero F. Alesina,F. A. Wenger,Anastasios Deligiannis,Eduard Szuczik,Stephan Petersenn,Andreas Ommer,Harald Groeben,K. Peitgen,Onno E. Janssen,Thomas Philipp,Hartmut P. H. Neumann,Kurt Werner Schmid,Klaus Mann +13 more
TL;DR: The posterior retroperitoneoscopic adrenalectomy is a safe and fast procedure and in experienced hands, this method represents the ideal approach in adrenal surgery.
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Inflammatory reactions and severe neutropenia in mice lacking the transcriptional repressor Gfi1.
Holger Karsunky,Hui Zeng,Thorsten Schmidt,Branko Zevnik,Reinhart Kluge,Kurt Werner Schmid,Ulrich Dührsen,Tarik Möröy +7 more
TL;DR: It is concluded that Gfi1 influences the differentiation of myeloid precursors into granulocytes or monocytes and acts in limiting the inflammatory immune response.