Martina Ulrich

TL;DR: In CF patients with established lung disease, Pseudomonas aeruginosa was located within hypoxic mucopurulent masses in airway lumens, and in vitro studies revealed that CF-specific increases in epithelial O(2) consumption, linked to increased airway surface liquid (ASL) volume absorption and mucus stasis, generated steep hypoxic gradients within thickened mucus on CF epithelial surfaces prior to infection.

TL;DR: Inhibition of Asm as a new treatment strategy for cystic fibrosis is suggested because it shows that ceramide age-dependently accumulates in the respiratory tract of uninfected Cftr-deficient mice and prevents all pathological findings, including susceptibility to infection.

TL;DR: PNSG is a candidate for use in a vaccine to protect against S. aureus infection and protected mice against kidney infections and death from strains that produced little PNSG in vitro.

TL;DR: It is demonstrated that anaerobic in vitro growth conditions lead to increased polysaccharide expression in both S. aureus and S. epidermidis, which suggests a mechanism whereby ica gene expression and poly Saccharide production may act as a virulence factor in an an aerobic environment in vivo.

TL;DR: Colistin-tobramycin combinations are more efficient than respective single antibiotics for killing P. aeruginosa in biofilms in vitro, and they significantly reduced P.aerug inosa cell counts in a rat lung infection model and in patients with cystic fibrosis.