Kusum Pandit

TL;DR: The down-regulation of let-7d in IPF and the profibrotic effects of this down- regulation in vitro and in vivo suggest a key regulatory role for this microRNA in preventing lung fibrosis.

TL;DR: It is shown that miRNA genes can be transcribed from promoters located several kilobases away and that their promoters share the same general features as those of protein coding genes, but miRNA transcript organization is more complex.

TL;DR: This is the first demonstration of a successful strategy to inhibit tumor STAT3 signaling via systemic administration of a selective STAT3 inhibitor, thereby paving the way for broad clinical development and having therapeutic implications beyond STAT3 to other “undruggable” targets in human cancers.

TL;DR: Comparison of IPF methylation patterns to lung cancer or control samples revealed that IPF lungs display an intermediate methylation profile, partly similar to Lung cancer and partlySimilar to control with 402 differentially methylated CpG islands overlapping between IPF and cancer.

TL;DR: The potential role of miR-154, one of multiple chr14q32 microRNA cluster members up-regulated in IPF and a regulator of fibroblast migration and proliferation, should be further explored in IPf.