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Danith H. Ly
Researcher at Carnegie Mellon University
Publications - 76
Citations - 4079
Danith H. Ly is an academic researcher from Carnegie Mellon University. The author has contributed to research in topics: Nucleic acid & Peptide nucleic acid. The author has an hindex of 30, co-authored 75 publications receiving 3659 citations. Previous affiliations of Danith H. Ly include University of Pittsburgh & Scripps Research Institute.
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Mitotic misregulation and human aging.
TL;DR: Measurements ofenger RNA levels in actively dividing fibroblasts isolated from young, middle-age, and old-age humans and humans with progeria suggest that an underlying mechanism of the aging process involves increasing errors in the mitotic machinery of dividing cells in the postreproductive stage of life.
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First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy
Malabika Sen,Sufi M. Thomas,Seungwon Kim,Joanne I. Yeh,Robert L. Ferris,Jonas T. Johnson,Umamaheswar Duvvuri,Jessica K. Lee,Nivedita Sahu,Sonali Joyce,Maria L. Freilino,Haibin Shi,Changyou Li,Danith H. Ly,Srinivas Rapireddy,Jonathan P. Etter,Pui-Kai Li,Lin Wang,Simion I. Chiosea,Raja R. Seethala,William E. Gooding,Xiaomin Chen,Naftali Kaminski,Kusum Pandit,Daniel Johnson,Jennifer R. Grandis +25 more
TL;DR: This is the first demonstration of a successful strategy to inhibit tumor STAT3 signaling via systemic administration of a selective STAT3 inhibitor, thereby paving the way for broad clinical development and having therapeutic implications beyond STAT3 to other “undruggable” targets in human cancers.
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High Yield, Large Scale Synthesis of Thiolate-Protected Ag7 Clusters
TL;DR: The approach developed in this work provides some insight into the cluster growth kinetics and may be extendable to the synthesis of other sized silver nanoclusters.
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A Simple γ-Backbone Modification Preorganizes Peptide Nucleic Acid into a Helical Structure
Anca Dragulescu-Andrasi,Srinivas Rapireddy,Brian M Frezza,Chakicherla Gayathri,Roberto R. Gil,Danith H. Ly +5 more
TL;DR: It is shown that a simple backbone modification at the γ-position of the N-(2-aminoethyl) glycine unit can transform a randomly folded PNA into a helical structure.
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Novel binding and efficient cellular uptake of guanidine-based peptide nucleic acids (GPNA).
TL;DR: The modified PNA recognizes and binds to the complementary DNA strand in accordance with Watson-Crick recognition rules, but unlike polypyrimidine PNA which binds to DNA in 2:1 stoichiometry, themodified PNA binds to complementary DNA in a 1:1 ratio to form a highly stable duplex.