K
Kwong Wai Choy
Researcher at The Chinese University of Hong Kong
Publications - 214
Citations - 7029
Kwong Wai Choy is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Prenatal diagnosis & Gene. The author has an hindex of 43, co-authored 195 publications receiving 5831 citations. Previous affiliations of Kwong Wai Choy include Utrecht University & Royal Children's Hospital.
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Journal ArticleDOI
Aqueous humor levels of vascular endothelial growth factor and pigment epithelium-derived factor in polypoidal choroidal vasculopathy and choroidal neovascularization.
Jian-Ping Tong,Wai-Man Chan,David T.L. Liu,Timothy Y Y Lai,Kwong Wai Choy,Chi Pui Pang,Dennis S.C. Lam +6 more
TL;DR: VEGF and PEDF factors were coexpressed and increased with positive correlation in aqueous humor of eyes with active PCV, and the different levels of both factors in eyes of PCV and AMD might suggest distinct clinical entities or different angiogenesis courses between PCv and AMD.
Journal ArticleDOI
Therapeutic potentials of gene silencing by RNA interference: principles, challenges, and new strategies.
Yan Deng,Chi Chiu Wang,Kwong Wai Choy,Quan Du,Jiao Chen,Qin Wang,Lu Li,Tony K.H. Chung,Tao Tang +8 more
TL;DR: The principles of RNA interference are described, the therapeutic potential in various diseases is reviewed and the new strategies for in vivo delivery of RNAi to overcome the challenges are discussed.
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Prevalence of recurrent pathogenic microdeletions and microduplications in over 9500 pregnancies
Francesca Romana Grati,Denise Molina Gomes,Jose Ferreira,Céline Dupont,Viola Alesi,Laetitia Gouas,Nina Horelli-Kuitunen,Kwong Wai Choy,Sandra García-Herrero,Alberto González de la Vega,Krzysztof Piotrowski,Rita Genesio,Gloria Queipo,Barbara Malvestiti,Bérénice Hervé,Brigitte Benzacken,Antonio Novelli,Philippe Vago,Kirsi Piippo,Tak Yeung Leung,Federico Maggi,Thibault Quibel,Anne Claude Tabet,Giuseppe Simoni,François Vialard +24 more
TL;DR: The aim of this study was to provide the frequencies of the submicroscopic defects detectable by PNBoBsTM under different prenatal indications.
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TBX6 Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis
Nan Wu,Ming X,Xiao J,Z. Wu,Xiaoli Chen,Marwan Shinawi,Shen Y,Yu G,Jiaqi Liu,Xie H,Zoran Gucev,S. B. Liu,Yang N,Hussam Al-Kateb,Chen J,Zhang J,Natalie Hauser,Zhang T,Tasic,Pengfei Liu,Su X,Xuedong Pan,Liu C,Lu Wang,Joseph J. Shen,Yi Chen,Kwong Wai Choy,Jian Wang,Quan Wang,Shu Li,Weichen Zhou,Jun Guo,Y. F. Wang,Zhang C,Zhao H,An Y,Ye Zhao,Z. A. Liu,Yuzhi Zuo,Tian Y,Weng X,Vernon R. Sutton,Hui Wang,Ming Y,Shashikant Kulkarni,Zhong Tp,Philip F. Giampietro,Sally L. Dunwoodie,Cheung Sw,Xue Zhang,Li Jin,Lupski,Guixing Qiu,Feng Zhang +53 more
TL;DR: Compound inheritance of a rare null mutation and a hypomorphic allele of TBX6 accounted for up to 11% of congenital scoliosis cases in the series that was analyzed, and in vitro functional assays suggested that the risk haplotype is a Hypomorphic allele.
Journal ArticleDOI
MiR-222 Overexpression Confers Cell Migratory Advantages in Hepatocellular Carcinoma through Enhancing AKT Signaling
Queenie W-L Wong,Arthur K-K Ching,Anthony Wh Chan,Kwong Wai Choy,Ka Fai To,Paul B.S. Lai,Nathalie Wong +6 more
TL;DR: The study showed that miR-222 overexpression is common in HCC and could confer metastatic potentials in H CC cells, possibly through activating AKT signaling.