N
Nan Wu
Researcher at Peking Union Medical College Hospital
Publications - 159
Citations - 4075
Nan Wu is an academic researcher from Peking Union Medical College Hospital. The author has contributed to research in topics: Medicine & Exome sequencing. The author has an hindex of 21, co-authored 118 publications receiving 2338 citations. Previous affiliations of Nan Wu include Peking Union Medical College & New York Academy of Medicine.
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Journal ArticleDOI
ceRNA in cancer: possible functions and clinical implications
TL;DR: The mechanisms and molecular bases of ceRNA networks are introduced, their roles in the pathogenesis of cancer as well as methods of predicting and validating ceRNA interplay are discussed and the possibilities of ceRNAs as diagnostic biomarkers or therapeutic targets are envisioned.
Journal ArticleDOI
TBX6 Null Variants and a Common Hypomorphic Allele in Congenital Scoliosis
Nan Wu,Ming X,Xiao J,Z. Wu,Xiaoli Chen,Marwan Shinawi,Shen Y,Yu G,Jiaqi Liu,Xie H,Zoran Gucev,S. B. Liu,Yang N,Hussam Al-Kateb,Chen J,Zhang J,Natalie Hauser,Zhang T,Tasic,Pengfei Liu,Su X,Xuedong Pan,Liu C,Lu Wang,Joseph J. Shen,Yi Chen,Kwong Wai Choy,Jian Wang,Quan Wang,Shu Li,Weichen Zhou,Jun Guo,Y. F. Wang,Zhang C,Zhao H,An Y,Ye Zhao,Z. A. Liu,Yuzhi Zuo,Tian Y,Weng X,Vernon R. Sutton,Hui Wang,Ming Y,Shashikant Kulkarni,Zhong Tp,Philip F. Giampietro,Sally L. Dunwoodie,Cheung Sw,Xue Zhang,Li Jin,Lupski,Guixing Qiu,Feng Zhang +53 more
TL;DR: Compound inheritance of a rare null mutation and a hypomorphic allele of TBX6 accounted for up to 11% of congenital scoliosis cases in the series that was analyzed, and in vitro functional assays suggested that the risk haplotype is a Hypomorphic allele.
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Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk.
TL;DR: It is found that Piezo1 deficiency in osteoblastic cells leads to loss of bone mass and spontaneous fractures with increased bone resorption, and PIEZO1 is identified as the major skeletal mechanosensor that tunes bone homeostasis.
Journal ArticleDOI
Identification of tumor immune infiltration-associated lncRNAs for improving prognosis and immunotherapy response of patients with non-small cell lung cancer.
Jie Sun,Zicheng Zhang,Siqi Bao,Congcong Yan,Ping Hou,Nan Wu,Jianzhong Su,Liangde Xu,Meng Zhou +8 more
TL;DR: The finding demonstrated the importance and value of lncRNAs in evaluating the immune infiltrate of the tumor and highlighted the potential of lNCRNA coupled with specific immune checkpoint factors as predictive biomarkers of ICI response to enable a more precise selection of patients.
Journal ArticleDOI
Reanalysis of Clinical Exome Sequencing Data
Pengfei Liu,Linyan Meng,Elizabeth A. Normand,Fan Xia,Xiaofei Song,Andrew R. Ghazi,Jill A. Rosenfeld,Pilar L. Magoulas,Alicia Braxton,Patricia A. Ward,Hongzheng Dai,Bo Yuan,Weimin Bi,Rui Xiao,Xia Wang,Theodore Chiang,Francesco Vetrini,Weimin He,Hanyin Cheng,Jie Dong,Charul Gijavanekar,Paul J. Benke,Jonathan A. Bernstein,Tanya N. Eble,Yasemen Eroglu,Deanna J. Erwin,Luis F. Escobar,James B. Gibson,Karen W. Gripp,Soledad Kleppe,Mary Kay Koenig,Andrea M. Lewis,Marvin R. Natowicz,Pedro Mancias,La Keesha Minor,Fernando Scaglia,Christian P. Schaaf,Haley Streff,Hilary J. Vernon,Crescenda L. Uhles,Elaine H. Zackai,Nan Wu,V. Reid Sutton,Arthur L. Beaudet,Donna M. Muzny,Richard A. Gibbs,Jennifer E. Posey,Seema R. Lalani,Chad A. Shaw,Christine M. Eng,James R. Lupski,Yaping Yang +51 more
TL;DR: Reanalysis of Clinical Exome Data and Diagnostic Yield As knowledge about genetic causes of disease improves, periodic reanalysis of clinical exome sequence could yield new genetic information.