Quan Du

TL;DR: The new method of 'Distance Weighted Discrimination (DWD)' is shown to be better than Support Vector Machines and Singular Value Decomposition for the adjustment of systematic microarray effects and of general use as a tool for the discrimination of systematic problems present in microarray data sets, including the merging of two breast tumor data sets completed on different microarray platforms.

TL;DR: The results demonstrate the feasibility of using charge-reversal functional gold nanoparticles as a means of improving the nucleic acid delivery efficiency.

TL;DR: This study provides direct evidence that the target recognition of siRNA is far more degenerative than previously considered and is instrumental in the understanding of RNAi specificity and may aid the computational prediction of RNA secondary structure.

TL;DR: The principles of RNA interference are described, the therapeutic potential in various diseases is reviewed and the new strategies for in vivo delivery of RNAi to overcome the challenges are discussed.

TL;DR: It is found that reduction of endogenous ERα protein levels and suppression of cancer cell growth could be achieved in MCF‐7 cells by miR‐22 overexpression in a way that can be recapitulated by the introduction of specific small interfering RNA against ERα.