K
Kym N Lowes
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 38
Citations - 3279
Kym N Lowes is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Plasmodium falciparum & Medicine. The author has an hindex of 19, co-authored 31 publications receiving 2706 citations. Previous affiliations of Kym N Lowes include Fremantle Hospital & University of Melbourne.
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Journal ArticleDOI
Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity.
Brodie L Bailey,William Nguyen,Anna Ngo,Christopher D. Goodman,Maria R. Gancheva,Paola Favuzza,Laura M. Sanz,Francisco-Javier Gamo,Kym N Lowes,Geoffrey I. McFadden,Danny W. Wilson,Benoît Laleu,Stephen Brand,Paul F. Jackson,Alan F. Cowman,Brad E. Sleebs,Brad E. Sleebs +16 more
TL;DR: In this paper, the 2-(N-phenyl carboxamide) triazolopyrimidine (TPCA) scaffold was used to detect the asexual stages of the P. falciparum parasite.
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Structure activity refinement of phenylsulfonyl piperazines as antimalarials that block erythrocytic invasion
William Nguyen,William Nguyen,Madeline G Dans,Madeline G Dans,Anna Ngo,Anna Ngo,Maria R. Gancheva,Ornella Romeo,Sandra Duffy,Tania F. de Koning-Ward,Kym N Lowes,Kym N Lowes,Helene Jousset Sabroux,Helene Jousset Sabroux,Vicky M. Avery,Danny W. Wilson,Danny W. Wilson,Paul R. Gilson,Brad E. Sleebs,Brad E. Sleebs +19 more
TL;DR: In this article, a screen of the Medicines for Malaria Venture Pathogen Box employing transgenic P.falciparum parasites expressing the nanoluciferase bioluminescent reporter identified the phenylsulfonyl piperazine class as a specific inhibitor of erythrocyte invasion.
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Property activity refinement of 2-anilino 4-amino substituted quinazolines as antimalarials with fast acting asexual parasite activity.
Trent D. Ashton,Anna Ngo,Paola Favuzza,Hayley E. Bullen,Maria R. Gancheva,Ornella Romeo,Molly Parkyn Schneider,Nghi Nguyen,Ryan W.J. Steel,Sandra Duffy,Kym N Lowes,Helene Jousset Sabroux,Vicky M. Avery,Justin A Boddey,Danny W. Wilson,Alan F. Cowman,Paul R. Gilson,Brad E. Sleebs,Brad E. Sleebs +18 more
TL;DR: In this article, the physicochemical properties of the 2-anilino quinazoline antimalarial class were improved with the aim of improving aqueous solubility and metabolism and to reduce adverse promiscuity.
Journal ArticleDOI
RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting
Julie Healer,Jennifer K. Thompson,Karen L. Mackwell,Cecille D. Browne,Benjamin A Seager,Anna Ngo,Kym N Lowes,Sarah E. Silk,David Pulido,Lloyd King,Jayne M. Christen,Amy R. Noe,V. Kotraiah,Paul J. Masendycz,Rajkannan Rajagopalan,Leanne J. Lucas,Marianne M. Stanford,Lorraine Soisson,Carter L. Diggs,Robin H. Miller,Susan Youll,Kaye Wycherley,Simon J. Draper,Alan F. Cowman +23 more
TL;DR: In this article , a protein-in-adjuvant blood stage malaria vaccine based on a combination of RH5, Ripr and CyRPA was proposed to provide improved neutralizing activity against P. falciparum in vitro.
Journal ArticleDOI
Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.
William Nguyen,William Nguyen,Erinna F. Lee,Marco Evangelista,Mihwa Lee,Tiffany J Harris,Peter M. Colman,Peter M. Colman,Nicholas A. Smith,Luke B Williams,Kate E. Jarman,Kate E. Jarman,Kym N Lowes,Kym N Lowes,Cécile Haeberli,Cécile Haeberli,Jennifer Keiser,Jennifer Keiser,Brian J. Smith,W. Douglas Fairlie,Brad E. Sleebs,Brad E. Sleebs +21 more
TL;DR: In this paper, structural differences in the human and schistosome BCL-2 (sBCL-2) pro-survival proteins were exploited to exploit structural differences between the two proteins.