F
Francisco-Javier Gamo
Researcher at GlaxoSmithKline
Publications - 99
Citations - 5981
Francisco-Javier Gamo is an academic researcher from GlaxoSmithKline. The author has contributed to research in topics: Plasmodium falciparum & Malaria. The author has an hindex of 32, co-authored 87 publications receiving 4947 citations.
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Journal ArticleDOI
Thousands of chemical starting points for antimalarial lead identification
Francisco-Javier Gamo,Laura M. Sanz,J. Vidal,Cristina de Cozar,Emilio Alvarez,J.L. Lavandera,Dana E. Vanderwall,Darren V. S. Green,Vinod Kumar,Samiul Hasan,James R. Brown,Catherine E. Peishoff,Lon R. Cardon,Jose F. Garcia-Bustos +13 more
TL;DR: Chemical structures and associated data suggest several novel mechanisms of antimalarial action, such as inhibition of protein kinases and host–pathogen interaction related targets.
Journal ArticleDOI
Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond.
Wesley C. Van Voorhis,John H. Adams,Roberto Adelfio,Roberto Adelfio,Vida Ahyong,Myles H. Akabas,Pietro Alano,Aintzane Alday,Yesmalie Alemán Resto,Aishah Alsibaee,Ainhoa Alzualde,Katherine T. Andrews,Katherine T. Andrews,Simon V. Avery,Vicky M. Avery,Lawrence Ayong,Mark Baker,Stephen Baker,Stephen Baker,Choukri Ben Mamoun,Sangeeta N. Bhatia,Quentin D. Bickle,Lotfi Bounaadja,Tana Bowling,Jürgen Bosch,Lauren E. Boucher,Fabrice Fekam Boyom,José Brea,Marian P. Brennan,Audrey Burton,Conor R. Caffrey,Grazia Camarda,Manuela Carrasquilla,Manuela Carrasquilla,Dee A. Carter,Maria B. Cassera,Ken Chih-Chien Cheng,Worathad Chindaudomsate,Anthony J. Chubb,Beatrice L. Colon,Daisy D. Colón-López,Yolanda Corbett,Gregory J. Crowther,Noemi Cowan,Noemi Cowan,Sarah D'Alessandro,Na Le Dang,Michael J. Delves,Joseph L. DeRisi,Alan Y. Du,Sandra Duffy,Shimaa Abd El-Salam El-Sayed,Shimaa Abd El-Salam El-Sayed,Michael T. Ferdig,José A. Fernández Robledo,David A. Fidock,Isabelle Florent,Patrick Valere Tsouh Fokou,Ani Galstian,Francisco-Javier Gamo,Suzanne Gokool,Ben Gold,Todd R. Golub,Gregory M. Goldgof,Rajarshi Guha,W. Armand Guiguemde,Nil Gural,R. Kiplin Guy,Michael Adsetts Edberg Hansen,Kirsten K. Hanson,Kirsten K. Hanson,Andrew Hemphill,Rob Hooft van Huijsduijnen,Takaaki Horii,Paul Horrocks,Tyler B. Hughes,Christopher D. Huston,Ikuo Igarashi,Katrin Ingram-Sieber,Katrin Ingram-Sieber,Maurice A. Itoe,Ajit Jadhav,Amornrat Naranuntarat Jensen,Laran T. Jensen,Rays H. Y. Jiang,Annette Kaiser,Jennifer Keiser,Jennifer Keiser,Thomas J. Ketas,Sébastien Kicka,Sunyoung Kim,Kiaran Kirk,Vidya Prasanna Kumar,Dennis E. Kyle,Maria Jose Lafuente,Scott M. Landfear,Nathan Lee,Sukjun Lee,Adele M. Lehane,Fengwu Li,David Little,Liqiong Liu,Manuel Llinás,María Isabel Loza,Aristea Lubar,Leonardo Lucantoni,Isabelle S Lucet,Louis Maes,Dalu Mancama,Nuha R. Mansour,Sandra March,Sheena McGowan,Iset Medina Vera,Stephan Meister,Luke Mercer,Jordi Mestres,Alvine Ngoutane Mfopa,Raj N. Misra,Seunghyun Moon,John P. Moore,Francielly Morais Rodrigues da Costa,Joachim Müller,Arantza Muriana,Stephen N. Hewitt,Bakela Nare,Carl Nathan,Nathalie Narraidoo,Sujeevi Nawaratna,Sujeevi Nawaratna,Kayode K. Ojo,Diana Ortiz,Gordana Panic,Gordana Panic,George Papadatos,Silvia Parapini,Kailash P. Patra,Ngoc Minh Pham,Sarah Prats,David Plouffe,Sally-Ann Poulsen,Anupam Pradhan,Celia Quevedo,Ronald J. Quinn,Christopher A. Rice,Mohamed Abdo Rizk,Mohamed Abdo Rizk,Andrea Ruecker,Robert P. St.Onge,Rafaela Salgado Ferreira,Jasmeet Samra,Natalie G. Robinett,Natalie G. Robinett,Ulrich Schlecht,Marjorie Schmitt,Filipe Silva Villela,Francesco Silvestrini,Robert E. Sinden,Dennis A. Smith,Thierry Soldati,Andreas Spitzmüller,Serge Maximilian Stamm,David J. Sullivan,William J. Sullivan,Sundari Suresh,Brian M. Suzuki,Yo Suzuki,S. Joshua Swamidass,Donatella Taramelli,Lauve R. Y. Tchokouaha,Anjo Theron,David Thomas,Kathryn F. Tonissen,Simon Townson,Abhai K. Tripathi,Valentin Trofimov,Kenneth O. Udenze,Imran Ullah,Cindy Vallières,Edgar Vigil,Joseph M. Vinetz,Phat Voong Vinh,Hoan Vu,Nao Aki Watanabe,Kate Weatherby,Pamela M. White,Andrew F. Wilks,Andrew F. Wilks,Elizabeth A. Winzeler,Edward J. Wojcik,Melanie Wree,Wesley Wu,Naoaki Yokoyama,Paul Henri Amvam Zollo,Nada Abla,Benjamin Blasco,Jeremy N. Burrows,Benoît Laleu,Didier Leroy,Thomas Spangenberg,Timothy N. C. Wells,Paul Willis +200 more
TL;DR: The results reveal the immense potential for translating the dispersed expertise in biological assays involving human pathogens into drug discovery starting points, by providing open access to new families of molecules, and emphasize how a small additional investment made to help acquire and distribute compounds, and sharing the data, can catalyze drug discovery for dozens of different indications.
Journal ArticleDOI
A novel multiple-stage antimalarial agent that inhibits protein synthesis
Beatriz Baragaña,Irene Hallyburton,Marcus C. S. Lee,Marcus C. S. Lee,Neil R. Norcross,Raffaella Grimaldi,Thomas D. Otto,William R. Proto,Andrew M. Blagborough,Stephan Meister,Grennady Wirjanata,Andrea Ruecker,Leanna M. Upton,Tara S. Abraham,Mariana Justino de Almeida,Anupam Pradhan,Achim Porzelle,María Santos Martínez,Judith M. Bolscher,Andrew Woodland,Suzanne Norval,Fabio Zuccotto,John Thomas,Frederick R. C. Simeons,Laste Stojanovski,Maria Osuna-Cabello,Patrick M. Brock,Thomas S. Churcher,Katarzyna A. Sala,Sara E. Zakutansky,María Belén Jiménez-Díaz,Laura M. Sanz,Jennifer Riley,Rajshekhar Basak,Michael Campbell,Vicky M. Avery,Robert W. Sauerwein,Koen J. Dechering,Rintis Noviyanti,Brice Campo,Julie A. Frearson,Iñigo Angulo-Barturen,Santiago Ferrer-Bazaga,Francisco-Javier Gamo,Paul G. Wyatt,Didier Leroy,Peter Siegl,Michael J. Delves,Dennis E. Kyle,Sergio Wittlin,Jutta Marfurt,Ric N. Price,Robert E. Sinden,Elizabeth A. Winzeler,Susan A. Charman,Lidiya Bebrevska,David W. Gray,Simon Campbell,Alan H. Fairlamb,Paul Willis,Julian C. Rayner,David A. Fidock,Kevin D. Read,Ian H. Gilbert +63 more
TL;DR: DDD107498 was developed from a screening programme against blood-stage malaria parasites and its molecular target has been identified as translation elongation factor 2 (eEF2), which is responsible for the GTP-dependent translocation of the ribosome along messenger RNA, and is essential for protein synthesis.
Journal ArticleDOI
Quinolone-3-Diarylethers: A New Class of Antimalarial Drug
Aaron Nilsen,Alexis N. LaCrue,Karen L. White,Isaac P. Forquer,R. Matthew Cross,Jutta Marfurt,Michael W. Mather,Michael J. Delves,David M. Shackleford,Fabián E. Sáenz,Joanne M. Morrisey,Jessica Anne Steuten,Tina Mutka,Yuexin Li,Grennady Wirjanata,Eileen Ryan,Sandra Duffy,Jane X. Kelly,Boni F. Sebayang,Anne-Marie Zeeman,Rintis Noviyanti,Robert E. Sinden,Clemens H. M. Kocken,Ric N. Price,Ric N. Price,Vicky M. Avery,Iñigo Angulo-Barturen,María Belén Jiménez-Díaz,Santiago Ferrer,Esperanza Herreros,Laura M. Sanz,Francisco-Javier Gamo,Ian Bathurst,Jeremy N. Burrows,Peter Siegl,R. Kiplin Guy,Rolf W. Winter,Akhil B. Vaidya,Susan A. Charman,Dennis E. Kyle,Roman Manetsch,Michael K. Riscoe +41 more
TL;DR: ELQ-300, a 4(1H)-quinolone-3-diarylether, which targets the liver and blood stages, including the forms that are crucial to disease transmission (gametocytes, zygotes, and ookinetes), has potential as a new drug for the treatment, prevention, and, ultimately, eradication of human malaria.
Journal ArticleDOI
Structure-Guided Lead Optimization of Triazolopyrimidine-Ring Substituents Identifies Potent Plasmodium falciparum Dihydroorotate Dehydrogenase Inhibitors with Clinical Candidate Potential
Jose M. Coteron,Maria L. Marco,Jorge Esquivias,Xiaoyi Deng,Karen L. White,John H. White,Maria Koltun,Farah El Mazouni,Sreekanth Kokkonda,Kasiram Katneni,Ravi K. Bhamidipati,David M. Shackleford,Iñigo Angulo-Barturen,Santiago Ferrer,María Belén Jiménez-Díaz,Francisco-Javier Gamo,Elizabeth J. Goldsmith,William N. Charman,Ian Bathurst,David M. Floyd,David Matthews,Jeremy N. Burrows,Pradipsinh K. Rathod,Susan A. Charman,Margaret A. Phillips +24 more
TL;DR: These studies have identified the first candidate in the triazolopyrimidine series to meet previously established progression criteria for efficacy and ADME properties, justifying further development of this compound toward clinical candidate status.